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Pak Functions Downstream of Dock to Regulate Photoreceptor Axon Guidance in Drosophila
TLDR
It is demonstrated that Drosophila p21-activated kinase (Pak) is required in a Dock pathway regulating R cell axon guidance and targeting, and Retinal expression of Pak rescues the R cell connectivity phenotype in dock mutants, establishing Pak as a critical regulator of axon advice and a downstream effector of Dock in vivo. Expand
Slit Stimulation Recruits Dock and Pak to the Roundabout Receptor and Increases Rac Activity to Regulate Axon Repulsion at the CNS Midline
TLDR
Evidence is presented that the SH3-SH2 adaptor protein Dreadlocks, the p21-activated serine-threonine kinase (Pak), and the Rac1/Rac2/Mtl small GTPases can function during Robo repulsion and that Rac can function in both attractive and repulsive axon guidance. Expand
Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway.
TLDR
A new Notch allele, Nsu42c, is presented that is associated with a missense mutation within the fifth ankyrin repeat and represents a new class of viable NotCh allele that behaves similarly to mutations of deltex and further implicates the Ankyrin repeats in Notch function. Expand
Drosophila hygrosensation requires the TRP channels water witch and nanchung
TLDR
Two Drosophila melanogaster transient receptor potential channels needed for sensing humidity are identified: CG31284, named by us water witch (wtrw), which is required to detect moist air, and nanchung, which is involved in detecting dry air. Expand
Modulation of wingless signaling by Notch in Drosophila
TLDR
It is found that notch is necessary for the implementation of the Wingless signal in specifying normal wing development, and the possibility that Notch is directly involved in the reception of Wingless is discussed in the light of current models for the developmental action of Notch. Expand
A Drosophila homolog of LIM-kinase phosphorylates cofilin and induces actin cytoskeletal reorganization.
TLDR
Observations suggest that the LIMK-cofilin signaling pathway for regulating actin filament dynamics is evolutionarily conserved between Drosophila and mammals. Expand
dPak is required for integrity of the leading edge cytoskeleton during Drosophila dorsal closure but does not signal through the JNK cascade.
TLDR
It is concluded that dorsal closure requires Group I Pak function in both the amnioserosa and the epidermis, and may be a component of the signaling known to occur between these two tissues. Expand
Mutations in the heatshock cognate 70 protein (hsc4) modulate Notch signaling.
TLDR
This work identified mutations in Bag, the gene encoding clathrin heavy chain and a dominant mutation of the cytosolic 70 kDa heatshock cognate protein encoded by the hsc4 gene, as Notch signaling modifier, as well as nine complementation groups as modifiers of the hypomorphic Notch allele notchoid. Expand
Derailed regulates development of the Drosophila neuromuscular junction
TLDR
It is shown here that Wnt5 regulates the growth of the Drosophila neuromuscular junction (NMJ) by signaling through the Derailed receptor, and structure–function analyses of the Drl protein indicate that normal synaptic growth requires the extracellular Wnt inhibitory factor domain and the intracellular domain, which includes an atypical kinase. Expand
Growth cone choices of Drosophila motoneurons in response to muscle fiber mismatch
TLDR
Each motoneuron growth cone has a primary target preference, which is retained even when the numbers of the muscle fibers, and therefore their relative positions, are altered, suggesting that synaptic recognition by Drosophila mot oneuron growth cones relies on unique features of the individual muscle fibers. Expand
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