H. Hiemstra

Publications260
h-index42
Citations8,202
Highly Influential Citations21
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Selective enrichment of azide-containing peptides from complex mixtures.
A general method is described to sequester peptides containing azides from complex peptide mixtures, aimed at facilitating mass spectrometric analysis to study different aspects of proteome dynamics.… Expand
  • 81
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Organocatalytic enantioselective Pictet-Spengler approach to biologically relevant 1-benzyl-1,2,3,4-tetrahydroisoquinoline alkaloids.
A general procedure for the synthesis of 1-benzyl-1,2,3,4-tetrahydroisoquinolines was developed, based on organocatalytic, regio- and enantioselective Pictet-Spengler reactions (86-92% ee) of… Expand
  • 35
  • 3
Synthesis of N-Boc-protected 1-amino-3-alken-2-ols from allylic carbamates via palladium(II)-catalyzed oxidative cyclization
Methyl glyoxylate adducts of N-Boc-protected allylic amines cyclize in the presence of catalytic Pd(OAc) 2 and excess Cu(OAc) 2 in DMSO to 5-(1-alkenyl)-2-(methoxycarbonyl)oxazolidines. These… Expand
  • 48
  • 2
CuI‐Catalyzed Alkyne–Azide “Click” Cycloadditions from a Mechanistic and Synthetic Perspective
CuI-catalyzed alkyne–azide cycloaddition provides 1,4-disubstituted 1,2,3-triazoles with such efficiency and scope that the transformation has been described as “click” chemistry. An overview of the… Expand
  • 1,070
  • 1
Click chemistry as a route to cyclic tetrapeptide analogues: synthesis of cyclo-[Pro-Val-psi(triazole)-Pro-Tyr].
Despite the plethora of techniques to cyclize small peptides, a synthesis of cyclo-[(L)Pro-(L)Tyr-(L)Pro-(L)Val], a potent tyrosinase inhibitor, remains elusive because of the unfavorable transition… Expand
  • 151
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Inactivation of human immunodeficiency virus by gamma radiation and its effect on plasma and coagulation factors
The inactivation of HIV by gamma‐radiation was studied in frozen and liquid plasma; a reduction of the virus titer of 5 to 6 logs was achieved at doses of 5 to 10 Mrad at ‐80 degrees C and 2.5 Mrad… Expand
  • 64
  • 1
Enantioselective copper-catalysed propargylic substitution: synthetic scope study and application in formal total syntheses of (+)-anisomycin and (-)-cytoxazone.
A copper catalyst with a chiral pyridine-2,6-bisoxazoline (pybox) ligand was used to convert a variety of propargylic esters with different side chains (R=Ar, Bn, alkyl) into their amine counterparts… Expand
  • 75
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Unequivocal determination of complex molecular structures using anisotropic NMR measurements
Picking structures out of a lineup Pharmaceutical research relies critically on determining the correct structures of numerous complex molecules. When well-ordered crystals are not available for… Expand
  • 45
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A novel strategy for the synthesis of medium-sized lactams.
[reaction: see text] A novel method for the synthesis of medium-sized lactams based on an auxiliary-mediated combined tethered/templated strategy is presented. Cyclization by a tethered ring-closing… Expand
  • 41
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Distribution of newly synthesized lipoprotein over the outer membrane and the peptidoglycan sacculus of an Escherichia coli lac-lpp strain.
The insertion of newly synthesized lipoprotein molecules into the cell wall of Escherichia coli was studied topographically by immunoelectron microscopy. Lipoprotein was briefly induced with… Expand
  • 22
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