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Calls out of chaos: the adaptive significance of nonlinear phenomena in mammalian vocal production
Abstract Recent work on human vocal production demonstrates that certain irregular phenomena seen in human pathological voices and baby crying result from nonlinearities in the vocal productionExpand
ABSTRACT To establish a framework for discussing mammalian vocalizations, relevant terminology and concepts from the theory of nonlinear dynamics are introduced. It is suggested that a variety ofExpand
Bifurcations in an asymmetric vocal-fold model.
A two-mass model of vocal-fold vibrations is analyzed with methods from nonlinear dynamics. Bifurcations are located in parameter planes of physiological interest (subglottal pressure, stiffness ofExpand
Spontaneous synchronization of coupled circadian oscillators.
In mammals, the circadian pacemaker, which controls daily rhythms, is located in the suprachiasmatic nucleus (SCN). Circadian oscillations are generated in individual SCN neurons by a molecularExpand
Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS).
PERIOD (PER) proteins are central components within the mammalian circadian oscillator, and are believed to form a negative feedback complex that inhibits their own transcription at a particularExpand
Coupling governs entrainment range of circadian clocks
Circadian clocks are endogenous oscillators driving daily rhythms in physiology and behavior. Synchronization of these timers to environmental light–dark cycles (‘entrainment’) is crucial for anExpand
Biological profiling of gene groups utilizing Gene Ontology.
We present a statistical framework that tests whether functions, processes or locations described in the Gene Ontology are significantly enriched within a group of interesting genes when compared to a reference group. Expand
Modeling feedback loops of the Mammalian circadian oscillator.
The suprachiasmatic nucleus governs daily variations of physiology and behavior in mammals. Within single neurons, interlocked transcriptional/translational feedback loops generate circadian rhythmsExpand
Bifurcation analysis of the regulatory modules of the mammalian G1/S transition
This paper focuses on the role of small modules and feedbacks in the gene-protein network governing the G1/S transition in mammalian cells. Expand
Mathematical Modeling Identifies Inhibitors of Apoptosis as Mediators of Positive Feedback and Bistability
We show that inhibition of caspase-3 (Casp3) and Casp9 by inhibitors of apoptosis (IAPs) results in an implicit positive feedback, since cleaved Casp3 augments its own activation by sequestering IAPs away from Casp 9. Expand