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The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer
TLDR
Bone marrow reconstitution experiments show that Nlrp3 gene expression and function in hematopoietic cells, rather than intestinal epithelial cells or stromal cells, is responsible for protection against increased tumorigenesis, suggesting that the inflammasome functions as an attenuator of colitis and CAC.
Risk of melanoma and nonmelanoma skin cancer among patients with inflammatory bowel disease.
TLDR
Inflammatory bowel disease is associated with an increased incidence of melanoma and nonmelanoma skin cancer, and the risk of NMSC is increased by use of biologics and thiopurines, respectively, and patients with IBD should be counseled and monitored for skin cancer.
The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD With the European Crohn's and Colitis Organization: When to Start, When to Stop, Which Drug to
TLDR
Preliminary evidence suggests that a substantial proportion of patients in clinical remission for >1 year, without signs of active inflammation can remain in remission after stopping treatment, and there are insufficient data to make recommendations on when to stop anti-TNF therapy.
Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation.
TLDR
Findings indicate a major role of monocyte/macrophage dysfunction in the pathophysiology of GvHD and strongly suggest a future risk assessment or even donor selection through NOD2/CARD15 typing.
Lactobacillus GG in inducing and maintaining remission of Crohn's disease
TLDR
This study could not demonstrate a benefit of L. GG in inducing or maintaining medically induced remission in CD, and the primary end point was sustained remission, defined as freedom from relapse at the 6 months follow-up visit.
Modulation of the Intestinal Microbiota Alters Colitis-Associated Colorectal Cancer Susceptibility
TLDR
It is demonstrated that the severity of chronic colitis directly correlates to colorectal tumor development and that bacterial-induced inflammation drives progression from adenoma to invasive carcinoma, the first direct demonstration that manipulation of the intestinal microbiota alters the development of CAC.
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