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Population pharmacokinetics of imatinib and the role of α1-acid glycoprotein
TLDR
Because of the high pharmacokinetic variability of imatinib and the reported relationships between its plasma concentration and efficacy and toxicity, the usefulness of therapeutic drug monitoring as an aid to optimizing therapy should be further investigated.
Population pharmacokinetics of imatinib and the role of alpha-acid glycoprotein.
TLDR
Because of the high pharmacokinetic variability of imatinib and the reported relationships between its plasma concentration and efficacy and toxicity, the usefulness of therapeutic drug monitoring as an aid to optimizing therapy should be further investigated.
Detection of oligoclonal free kappa chains in the absence of oligoclonal IgG in the CSF of patients with suspected multiple sclerosis
TLDR
Oligoclonal free kappa bands in the CSF are related to the dissemination of MS lesions and may be a substitute for oligOClonal IgG in the McDonald’s criteria for diagnosis of MS.
Evaluation of an Intrathecal Immune Response in Amyotrophic Lateral Sclerosis Patients Implanted with Encapsulated Genetically Engineered Xenogeneic Cells
TLDR
It is demonstrated that encapsulated xenogeneic cells implanted intrathecally can survive for up to 20 weeks in the absence of immunosuppression and that neither CNTF nor the presence of antibodies against bovine fetuin elicit any adverse side effects in the implanted patients.
Assessing multiple sclerosis activity: is the in vitro production of tumor necrosis factor-α, interleukins 2, 6, 4, and 10, and immunoglobulin G of value?
TLDR
The enhanced production of IL-10 detected before or at relapse with AZA and IFN-β1a (trends) may interfere with initiation of the immune reaction and with the development of new CNS lesions.
In vitro cytokine profiles as indicators of relapse activity and clinical course in multiple sclerosis
TLDR
Both the weight of clinical parameters and of methodology used in results obtained in cytokine analysis in MS are stressed, as well as the cinetics of cytokine production.
ID6 Cost-Effectiveness of Liposomal Daunorubicin Versus Liposomal Doxorubicin in Kaposi Sarcoma
TLDR
A decision analysis model identifies Daunoxome as the most cost-effective and least expensive agent in the treatment of KS.
4CPS-145 Pharmacogenetics as a tool in dose adjustment of immunosuppressive drugs: a case report
TLDR
Characterisation of the cytochrome 3A5 genotype can be a predictive means of tacrolimus dose optimisation, permitting the achievement of effective Cres while avoiding toxic effects, and is important to raise awareness in the healthcare teams.
Clinical consequences of imatinib plasma concentrations variability in hemato-oncologic patients
TLDR
The large pharmacokinetics variability, associated to the pharmacokinetic-pharmacodynamic relationship uncovered are arguments to further investigate the usefulness of individualizing imatinib prescription based on TDM.
3PC-004 What happens when insulin aspart is diluted in dextrose?
TLDR
The kinetics shows that the insulin glycation phenomenon seems to increase with the contact time between insulin and glucose until a plateau is reached after 24 hour of contact, and showed the phenomenon of insulin aspart glycation.