H. Hechtman

Publications365
h-index58
Citations12,741
Highly Influential Citations239
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Increased platelet reactivity and circulating monocyte-platelet aggregates in patients with stable coronary artery disease.
OBJECTIVES We sought to examine whether patients with stable coronary artery disease (CAD) have increased platelet reactivity and an enhanced propensity to form monocyte-platelet aggregates. … Expand
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Hepatic‐Portal Venous Gas in Adults: Etiology, Pathophysiology and Clinical Significance
The roentgenographic finding of hepatic-portal venous gas (HPVG) has been reported extensively in the pediatric and radiology literature. The surgical implications and clinical significance have yet… Expand
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In vivo tracking of platelets: circulating degranulated platelets rapidly lose surface P-selectin but continue to circulate and function.
To examine the hypothesis that surface P-selectin-positive (degranulated) platelets are rapidly cleared from the circulation, we developed novel methods for tracking of platelets and measurement of… Expand
  • 545
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Intestinal reperfusion injury is mediated by IgM and complement.
Intestinal ischemia-reperfusion injury is dependent on complement. This study examines the role of the alternative and classic pathways of complement and IgM in a murine model of intestinal… Expand
  • 272
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Identification of a specific self-reactive IgM antibody that initiates intestinal ischemia/reperfusion injury.
Reperfusion injury of ischemic tissue represents an acute inflammatory response that can cause significant morbidity and mortality. The mechanism of injury is not fully elucidated, but recent studies… Expand
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Pathophysiology of ischaemia reperfusion injury: Central role of the neutrophil
Ischaemia is a common clinical event leading to local and remote injury. Evidence indicates that tissue damage is largely caused by activated neutrophils which accumulate when the tissue is… Expand
  • 522
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Reperfusion injury of ischemic skeletal muscle is mediated by natural antibody and complement
Reperfusion of ischemic tissue induces an acute inflammatory response that can result in necrosis and irreversible cell injury to both local vascular endothelium and parenchyma. To examine the… Expand
  • 397
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Consequences of postoperative alterations in respiratory mechanics.
Abstract In patients undergoing extrathoracic surgical procedures, upper abdominal operations led to the most significant reductions in vital capacity, tidal volume, and functional residual capacity.… Expand
  • 226
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Soluble complement receptor type 1 ameliorates the local and remote organ injury after intestinal ischemia-reperfusion in the rat.
We examined the role of C activation in ischemia reperfusion injury by inhibiting C activation in a rat model of mesenteric arterial occlusion. In anesthetized rats, 60 min of mesenteric arterial… Expand
  • 255
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Neutrophil and Nonneutrophil‐Mediated Injury in Intestinal Ischemia‐Reperfusion
ObjectiveThe role of polymorphonuclear neutrophils (PMN) was examined in local and remote organ injury after intestinal ischemia-reperfusion. Summary Background DataPMN have been found to mediate the… Expand
  • 244
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