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Overexpression of c-Maf contributes to T-cell lymphoma in both mice and human.
TLDR
The results suggest that c-Maf might cause a type of T-cell lymphoma in both mice and humans and that ARK5, in addition to cyclin D2 and integrin beta(7), might be downstream target genes of c-maf leading to malignant transformation. Expand
Macrophage inflammatory protein‐1 alpha is produced by human multiple myeloma (MM) cells and its expression correlates with bone lesions in patients with MM
TLDR
The data indicate that MIP‐1α is produced by myeloma cells and possibly plays a role in the pathogenesis of bone lesions in MM patients. Expand
Down-regulation of PU.1 by methylation of distal regulatory elements and the promoter is required for myeloma cell growth.
TLDR
The data suggest that down-regulation of PU.1 is an essential step for the survival of a subset of myeloma cells and that up-regulation by demethylation agents or other types of agents may represent a new therapeutic strategy for treatment of multipleMyeloma patients. Expand
Expression of syndecan regulates human myeloma plasma cell adhesion to type I collagen.
TLDR
It is concluded that Syndecan acts as a matrix receptor on human myeloma cells but is not expressed by all tumors, suggesting that syndecan may participate in regulating myelomas cell adhesion to the bone marrow stromal matrix. Expand
Successful treatment of TAFRO syndrome, a variant type of multicentric Castleman disease with thrombotic microangiopathy, with anti-IL-6 receptor antibody and steroids
TLDR
It is suggested that hypercytokinemia in TAFRO syndrome inhibits ADAMTS13 activity, thereby inducing thrombotic microangiopathy. Expand
Clarithromycin attenuates autophagy in myeloma cells.
TLDR
CAM may halt the autophagy process after fusion of autophagosomes with lysosomes, which may explain how CAM, combined with thalidomide, augments the cytotoxic effects of the latter on MM cells and suggests that modification of Autophagy might represent a new approach for therapy of MM. Expand
Hypoxia reduces CD138 expression and induces an immature and stem cell-like transcriptional program in myeloma cells
TLDR
The present data suggest that a hypoxic microenvironment affects the phenotype of MM cells, which may correlate with disease progression, and it is proposed that hypoxia induces immature and stem cell-like transcription phenotypes in myeloma cells. Expand
Induction of cell cycle arrest and apoptosis in myeloma cells by cepharanthine, a biscoclaurine alkaloid.
TLDR
Data show, for the first time, that CEP has anti-myeloma effects by the activation of apoptotic pathways and blocking cell cycle progression via CDK inhibitors. Expand
Detection of inducible nitric oxide synthase (iNOS) mRNA by RT-PCR in ATL patients and HTLV-I infected cell lines: clinical features and apoptosis by NOS inhibitor
TLDR
The results suggest that NO may be involved in the invasive character of ATL cells as the NOS inhibitor can induce apoptosis in an ATL cell line, as it does in EBV- infected cell lines. Expand
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