• Publications
  • Influence
ADF/Cofilin-Mediated Actin Dynamics Regulate AMPA Receptor Trafficking during Synaptic Plasticity
Dendritic spines undergo actin-based growth and shrinkage during synaptic plasticity, in which the actin depolymerizing factor (ADF)/cofilin family of actin-associated proteins are important.Expand
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Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop
Ca2+-activated Cl− channels (CaCCs) are exceptionally well adapted to subserve diverse physiological roles, from epithelial fluid transport to sensory transduction, because their gating isExpand
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Explaining Calcium-Dependent Gating of Anoctamin-1 Chloride Channels Requires a Revised Topology
Rationale: Ca2+-activated Cl channels play pivotal roles in the cardiovascular system. They regulate vascular smooth muscle tone and participate in cardiac action potential repolarization in someExpand
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Bimodal Control of a Ca2+-Activated Cl− Channel by Different Ca2+ Signals
Ca2+-activated Cl− channels play important roles in a variety of physiological processes, including epithelial secretion, maintenance of smooth muscle tone, and repolarization of the cardiac actionExpand
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Molecular physiology of bestrophins: multifunctional membrane proteins linked to best disease and other retinopathies.
This article reviews the current state of knowledge about the bestrophins, a newly identified family of proteins that can function both as Cl(-) channels and as regulators of voltage-gated Ca(2+)Expand
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Identification of a lipid scrambling domain in ANO6/TMEM16F
Phospholipid scrambling (PLS) is a ubiquitous cellular mechanism involving the regulated bidirectional transport of phospholipids down their concentration gradient between membrane leaflets.Expand
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Anion Permeation in Ca2+-Activated Cl− Channels
  • Z. Qu, H. Hartzell
  • Chemistry, Medicine
  • The Journal of general physiology
  • 1 December 2000
Ca2+-activated Cl channels (ClCaCs) are an important class of anion channels that are opened by increases in cytosolic [Ca2+]. Here, we examine the mechanisms of anion permeation through ClCaCs fromExpand
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Tmem16A Encodes the Ca2+-activated Cl− Channel in Mouse Submandibular Salivary Gland Acinar Cells*
Activation of an apical Ca2+-dependent Cl− channel (CaCC) is the rate-limiting step for fluid secretion in many exocrine tissues. Here, we compared the properties of native CaCC in mouseExpand
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Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels.
Ca(2+)-activated Cl- channels (CaCCs) perform many important functions in cell physiology including secretion of fluids from acinar cells of secretory glands, amplification of olfactory transduction,Expand
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Molecular physiology of norepinephrine and serotonin transporters.
Cocaine- and antidepressant-sensitive norepinephrine and serotonin transporters (NETs and SERTs) are closely related members of the Na+/Cl- transporter gene family, whose other members includeExpand
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