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Mechanism of Action of Oral Fingolimod (FTY720) in Multiple Sclerosis
Fingolimod (FTY720) is a first-in-class orally bioavailable compound that has shown efficacy in advanced clinical trials for the treatment of multiple sclerosis (MS). In vivo, fingolimod isExpand
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New concepts in the immunopathogenesis of multiple sclerosis
Multiple sclerosis (MS) is a commonly occurring inflammatory and demyelinating neurological disease. It has been considered to be an autoimmune disorder mediated by CD4+ type 1 T helper cells, butExpand
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Acute disseminated encephalomyelitis: an update.
Acute disseminated encephalomyelitis (ADEM) is a monophasic autoimmune demyelinating disease of the central nervous system that typically follows a febrile infection or a vaccination. Children areExpand
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Guillain-Barré syndrome.
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Short-lived plasma blasts are the main B cell effector subset during the course of multiple sclerosis.
Multiple sclerosis is a chronic inflammatory and demyelinating disorder of the CNS with an unknown aetiology. Although intrathecal immunoglobulin G (IgG) synthesis is a key feature of the disease,Expand
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The role of macrophages in immune-mediated damage to the peripheral nervous system
Macrophage-mediated segmental demyelination is the pathological hallmark of autoimmune demyelinating polyneuropathies, including the demyelinating form of Guillain-Barré syndrome and chronicExpand
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Anti-&agr;4 integrin therapy for multiple sclerosis: Mechanisms and rationale
The symptoms, severity, and course of multiple sclerosis (MS) vary among patients, leading to complex treatment issues. In recent years, research has focused on specific adhesion molecules thatExpand
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Immunopathogenesis and immunotherapy of multiple sclerosis
Multiple sclerosis (MS) is a chronic disease of the CNS that is characterized by inflammation, demyelination and axonal injury. Although the etiology of MS is still unknown, many findings pointExpand
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Identification of a pathogenic antibody response to native myelin oligodendrocyte glycoprotein in multiple sclerosis
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. Although the cause of MS is still uncertain, many findings point toward an ongoing autoimmune response toExpand
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Phenotypes of the N88S Berardinelli–Seip congenital lipodystrophy 2 mutation
Recently, two missense mutations (N88S, S90L) in the Berardinelli–Seip congenital lipodystrophy gene have been identified in autosomal dominant distal hereditary motor neuropathy and Silver syndrome.Expand
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