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Tetrahydronaphthalene lignan compounds as potent anti-HIV type 1 agents.
- H. Hara, T. Fujihashi, T. Sakata, A. Kaji, H. Kaji
- Chemistry, Medicine
- AIDS research and human retroviruses
- 20 May 1997
The results suggested that THN derivatives interact with RT in a manner similar to but slightly different from that of other nonnucleoside HIV-1 RT inhibitors, which resulted in compounds with a high selective index. Expand
Random integration of SV40 in SV40-transformed, immortalized human fibroblasts.
The results suggest that no specific integration sites in the cellular genome exist which are a prerequisite for the immortalization process, and that none of these predominating sites is selected for during the crisis period. Expand
Inhibition of HIV type 1 RNA dimerization by antisense DNA corresponding to the 17-nucleotide sequence downstream from the splice donor site of HIV type 1 RNA.
This work constructed a model system using a synthetic HIV-1 RNA fragment, which dimerized at relatively low salt concentrations, and found that antisense DNAs complementary to the region upstream from the SD site did not hybridize with the dimer, although they inhibited RNA dimerization and also dissociated the preformed dimer. Expand
Molecular basis of the altered gag p19 protein (MA) of the transformation-defective mutant of Rous sarcoma virus, tdPH2010.
It is concluded that the point mutation caused the altered electrophoretic behavior of p19 of tdPH2010 and had no effect on the growth of infected cells. Expand
Anti-human immunodeficiency virus (HIV) activities of halogenated gomisin J derivatives, new nonnucleoside inhibitors of HIV type 1 reverse transcriptase
- T. Fujihashi, H. Hara, +5 authors A. Kaji
- Biology, Medicine
- Antimicrobial agents and chemotherapy
- 1 September 1995
Halogenated gomisin J (a derivative of lignan compound), represented by the bromine derivative 1506 [(6R, 7S, S-biar)-4,9-dibromo-3,10-dihydroxy-1,2,11,12-tetramethoxy-6, 7-dimethyl-5,6,7,8-… Expand
Effect of temperature on normal and SV40-transformed human fibroblasts.
These findings imply that cellular senescence remains fixed when viral transformation occurs and is rendered refractory to further age-associated alterations, which support previous findings that environmental alterations, such as temperature shift, can cause acceleration of cellularsenescence. Expand
Fixation of cellular aging processes by SV40 virus transformation
It was found that the population doubling time and cellular protein content increase as the cells enter phase III, whereas the activity of arginyl-tRNA transferase and the ability of chromosomal proteins to accept arginine at the NH 2 -terminal end diminished progressively during cellular senescence. Expand
Infection of terminally differentiated myotubes with Rous sarcoma virus (RSV): lack of DNA integration but presence of RSV mRNA.
It is concluded that host DNA synthesis is required for RSV integration, but, in contrast to the generally accepted concept, viral DNA integration is not an absolute requirement for transcription of the RSV genome. Expand
Presence of a hypervariable region within the hr2 domain of the host range determining sequences of the envelope protein gp85 (SU) of subgroup-A avian sarcoma-leukosis viruses
A phylogenetic analysis of the amino acid sequence of this region indicated that this intra- subgroup diversity was as great as or even greater than the inter-subgroup diversity found among other subgroups of ASLV. Expand
Infection of terminally differentiated myotubes with Rous sarcoma virus: reduced synthesis of env and v-src proteins.
- K. Hsia, H. Hara, R. Izutani, H. Park, M. Fujihara, A. Kaji
- Biology, Medicine
- The Journal of general virology
- 1 July 1992
It was found that only the viral gag and pol proteins were synthesized at levels similar to those synthesized in RSV-transformed fibroblasts; the synthesis of env and v-src proteins was significantly reduced in these infected myotubes. Expand