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Increased Endoplasmic Reticulum Stress in Atherosclerotic Plaques Associated With Acute Coronary Syndrome
TLDR
The findings suggest that ER stress-induced apoptosis of smooth muscle cells and macrophages may contribute to plaque vulnerability. Expand
Arterial Smooth Muscle Cell Heterogeneity: Implications for Atherosclerosis and Restenosis Development
TLDR
In vitro studies that demonstrate the presence of distinct SMC subpopulations in arteries of various species, including humans, are discussed and the relevance of an atheroma-prone phenotype to intimal thickening formation will be discussed. Expand
Heterogeneity of Smooth Muscle Cell Populations Cultured From Pig Coronary Artery
TLDR
The results show that 2 distinct SMC subpopulations can be recovered from the pig coronary artery media, and the study of these sub Populations will be useful for understanding the mechanisms of restenosis. Expand
Perivascular adipose tissue-secreted angiopoietin-like protein 2 (Angptl2) accelerates neointimal hyperplasia after endovascular injury.
TLDR
It is demonstrated that perivascular adipose tissue-secreted Angptl2 accelerates vascular inflammation and the subsequent CVD development and that maintaining a balance between pro- and anti-inflammatory adipokines likely protects non-CHD patients from developing CHD. Expand
Endothelial-like cells in chronic thromboembolic pulmonary hypertension: crosstalk with myofibroblast-like cells
TLDR
It is possible that the microenvironment created by the stabilized clot stimulates MFLCs to induce EC alterations and promoted the commercially available ECs to transit to other mesenchymal phenotypes and/or induced EC dysfunction. Expand
Endogenous Angiotensin II Induces Atherosclerotic Plaque Vulnerability and Elicits a Th1 Response in ApoE−/− Mice
TLDR
A new mechanism in plaque vulnerability is suggested demonstrating that angiotensin II, within the context of hypertension and hypercholesterolemia, independently from its hemodynamic effect behaves as a local modulator promoting the induction of vulnerable plaques probably via a T helper switch. Expand
Macrophage-Derived Angiopoietin-Like Protein 2 Accelerates Development of Abdominal Aortic Aneurysm
TLDR
Macrophage-derived AngPTl2 contributes to AAA development by inducing inflammation and degradation of extracellular matrix in the vessel wall, suggesting that targeting the Angptl2-induced inflammatory axis in macrophages could represent a new strategy for AAA therapy. Expand
Accuracy of OCT, grayscale IVUS, and their combination for the diagnosis of coronary TCFA: an ex vivo validation study.
TLDR
In the present study, neither OCT nor IVUS were optimal to detect TCFA, but the combined use of OCT and IVUS may improve TCFA detection accuracy. Expand
Phenotypic modulation of intima and media smooth muscle cells in fatal cases of coronary artery lesion.
TLDR
Intimal SMCs of all situations exhibit a phenotypic profile, suggesting that they have modulated into myofibroblasts (MFs), and the high accumulation of alpha-SMA-positive MFs in erosions compared with stable plaques correlates with the higher appearance of thrombotic complications in this situation. Expand
Intraleaflet haemorrhage is associated with rapid progression of degenerative aortic valve stenosis.
TLDR
Multivariate analysis has shown that the area of intraleaflet haemorrhage was the sole independent factor that positively correlated with ΔAVA and was associated with neovascularization and macrophage infiltration. Expand
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