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Correlation of EPHA2 overexpression with high microvessel count in human primary colorectal cancer
Evidence suggests that the erythropoietin‐producing hepatocellular (EPH) receptor tyrosine kinases (RTKs) and their ephrin (EFN) ligands are involved in human carcinogenesis. Expression of two of… Expand
alphaPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase.
p21-activated kinase (PAK) is a common effector protein of the small GTPases Cdc42 and Rac, leading to the activation of downstream mitogen activated protein kinases. PAK also mediates polarized… Expand
Effect of genotypic differences in CYP2C19 on cure rates for Helicobacter pylori infection by triple therapy with a proton pump inhibitor, amoxicillin, and clarithromycin
Proton pump inhibitors such as omeprazole and lansoprazole are mainly metabolized by CYP2C19 in the liver. The therapeutic effects of proton pump inhibitors are assumed to depend on CYP2C19 genotype… Expand
CYP2C19 genotype status and effect of omeprazole on intragastric pH in humans
Omeprazole is metabolized by genetically determined S‐mephenytoin 4′‐hydroxylase (CYP2C19) in the liver. This study aimed to determine whether the effect of omeprazole on intragastric pH depends on… Expand
Expression profile of EFNB1, EFNB2, two ligands of EPHB2 in human gastric cancer
- H. Kataoka, M. Tanaka, +11 authors H. Sugimura
- Medicine, Biology
- Journal of Cancer Research and Clinical Oncology
- 26 June 2002
Abstract Purpose. We have previously reported that EPHB2 is overexpressed in gastric cancer; however, the expression profiles of its ligands, EFNB1 and EFNB2, are unknown. This study was designed to… Expand
Immunohistochemical localization of angiotensin II receptor and local renin-angiotensin system in human colonic mucosa.
- Koki Hirasawa, Yoshihiko Sato, Y. Hosoda, Tastuo Yamamoto, H. Hanai
- The journal of histochemistry and cytochemistry…
- 1 April 2001
Angiotensin II (Ang II) regulates water and sodium transport in renal tubules and gastrointestinal tract. Two types of Ang II receptors have been cloned, but their distributions have not been… Expand
Postnatal development of masticatory organs in rats. III. Effects of mastication on the postnatal development of the M. masseter superficialis.
When suckling of rats was continued on days 17--25 after birth, the development of the M. masseter superficialis was inhibited: increase in the diameter and SDH activity of its muscle fibers was… Expand
Bile duct proliferation in atresia and related hepatic diseases. A morphological study.
CONGENITAL biliary atresia is used clinically to include both extrahepatic and intrahepatic atresia of the bile ducts. While there is considerable knowledge concerning the pathology of this disease,… Expand
Serotonin uptake and its modulation in rat jejunal enterocyte preparation.
- S. Takayanagi, H. Hanai, J. Kumagai, Emi Kaneko
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 March 1995
In order to determine the properties of the intestinal serotonin (5-HT) transport system, we studied 5-HT uptake by villous cell preparations isolated from the rat jejunum. These enterocytes,… Expand
Functional muscarinic m3 receptor expressed in gastric cancer cells stimulates tyrosine phosphorylation and MAP kinase
- M. Kodaira, M. Kajimura, K. Takeuchi, S. Lin, H. Hanai, E. Kaneko
- Biology, Medicine
- Journal of Gastroenterology
- 1 April 1999
Abstract: Human gastric cancer cells were used to examine the trophic effect of the muscarinic m3 receptor subtype. Expression of the m3 receptor was detected in five of eight cell lines examined,… Expand