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- Publications
- Influence
SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway.
- F. Oswald, U. Kostezka, +9 authors R. Schmid
- Medicine
- The EMBO journal
- 2002
Notch proteins are the receptors for an evolutionarily highly conserved signalling pathway that regulates numerous cell fate decisions during development. Signal transduction involves the… Expand
An X-chromosome linked locus contributes to abnormal placental development in mouse interspecific hybrids
- U. Zechner, M. Reule, +5 authors R. Fundele
- Biology, Medicine
- Nature Genetics
- 1 April 1996
Interspecific hybridization between closely related species is commonly associated with decreased fertility or viability of F1 hybrids. Thus, in mouse interspecific hybrids, several different hybrid… Expand
Visualization of the conservation of synteny between humans and pigs by heterologous chromosomal painting.
- G. Rettenberger, C. Klett, U. Zechner, Jürgen Kunz, W. Vogel, H. Hameister
- Biology, Medicine
- Genomics
- 20 March 1995
By comparative gene mapping, extended conservation of synteny between different mammalian species has become apparent. Mapping in these species could be accelerated by exact visualization of the… Expand
Abnormal myotonic dystrophy protein kinase levels produce only mild myopathy in mice
- G. Jansen, P. Groenen, +14 authors B. Wieringa
- Biology, Medicine
- Nature Genetics
- 1 July 1996
Myotonic dystrophy (DM) is commonly associated with CTG repeat expansions within the gene for DM–protein kinase (DMPK). The effect of altered expression levels of DMPK, which is ubiquitously… Expand
Cloning of a gene highly overexpressed in cancer coding for a novel KH-domain containing protein
- Friederike Müeller-Pillasch, U. Lacher, +10 authors T. Gress
- Biology, Medicine
- Oncogene
- 5 June 1997
In a previous large scale screen for differentially expressed genes in pancreatic cancer, we identified a gene highly overexpressed in cancer encoding a novel protein with four K-homologous (KH)… Expand
SHARP is a novel component of the Notch/RBP‐Jκ signalling pathway
- F. Oswald, U. Kostezka, +9 authors R. Schmid
- Biology
- 15 October 2002
Notch proteins are the receptors for an evolutionarily highly conserved signalling pathway that regulates numerous cell fate decisions during development. Signal transduction involves the… Expand
Expression and differential regulation of connective tissue growth factor in pancreatic cancer cells
- C. Wenger, V. Ellenrieder, +8 authors T. Gress
- Biology, Medicine
- Oncogene
- 28 January 1999
CTGF is an immediate early growth responsive gene that has been shown to be a downstream mediator of TGFβ actions in fibroblasts and vascular endothelial cells. In the present study hCTGF was… Expand
A high density of X-linked genes for general cognitive ability: a run-away process shaping human evolution?
- U. Zechner, M. Wilda, H. Kehrer-Sawatzki, W. Vogel, R. Fundele, H. Hameister
- Biology, Medicine
- Trends in genetics : TIG
- 1 December 2001
The incidence of mental disability is 30% higher in males than in females. We have examined entries in the OMIM database that are associated with mental disability and for several other common… Expand
Molecular Cloning and Characterization of the Human Protein Kinase D2
- Sabine Sturany, J. Van Lint, +9 authors T. Seufferlein
- Biology, Medicine
- The Journal of Biological Chemistry
- 2 February 2001
We have isolated the full-length cDNA of a novel human serine threonine protein kinase gene. The deduced protein sequence contains two cysteine-rich motifs at the N terminus, a pleckstrin homology… Expand
An animal model for Norrie disease (ND): gene targeting of the mouse ND gene.
- W. Berger, D. J. van de Pol, +6 authors H. Ropers
- Biology, Medicine
- Human molecular genetics
- 1996
In order to elucidate the cellular and molecular processes which are involved in Norrie disease (ND), we have used gene targeting technology to generate ND mutant mice. The murine homologue of the ND… Expand