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Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.
TLDR
The results have important implications for the clinical use of genetically modified tumor cells as therapeutic cancer vaccines and the levels of anti-tumor immunity reported previously in cytokine gene transfer studies involving live, transduced cells could be achieved through the use of irradiated cells alone.
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Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.
TLDR
The results suggest that the protein has a role in the normal secretion of metabolites and certain anti-cancer drugs into bile, urine, and directly into the lumen of the gastrointestinal tract.
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p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload
TLDR
It is shown that cardiac angiogenesis is crucially involved in the adaptive mechanism of cardiachypertrophy and that p53 accumulation is essential for the transition from cardiac hypertrophy to heart failure and that the anti-angiogenic property of p53 may have a crucial function in the transition.
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Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma model
TLDR
Gene therapy employing MSCs as a targeting vehicle for gene therapy of malignant brain neoplasms would be promising as a new therapeutic approach for refractory brain tumor.
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Detailed characterization of the mouse glioma 261 tumor model for experimental glioblastoma therapy
TLDR
It is presented that Gl261 cells carry point mutations in the K‐ras and p53 genes, which might help to study the antitumor effects of various therapeutic modalities, but the moderate immunogenicity of the cells should be considered.
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Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion.
TLDR
It is demonstrated that MSCs are the most potent component in hepatic differentiation, as revealed by directly xenografting into rat livers.
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Intravenous administration of glial cell line‐derived neurotrophic factor gene‐modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in the adult rat
TLDR
Results suggest that intravenous administration of hMSCs transfected with the GDNF gene using a fiber‐mutant adenovirus vector may be useful in the cerebral ischemia and may represent a new strategy for the treatment of stroke.
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BDNF gene-modified mesenchymal stem cells promote functional recovery and reduce infarct size in the rat middle cerebral artery occlusion model.
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High Level Calcineurin Activity Predisposes Neuronal Cells to Apoptosis*
TLDR
The data indicate that high level constitutive activity of calcineurin predisposes neuronal cells to cytochrome c/caspase-3 dependent apoptosis even under sublethal conditions.
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Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody…
TLDR
It is reported that MRK16 also detects P170 in the capillaries of some human brain samples, and MAb C219, a monoclonal antibody shown to react with P170, shows intense localization in selected skeletal muscle fibers and all cardiac muscle fibers in rat and human tissues.
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