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Hydroxyeicosanoids Bind to and Activate the Low Affinity Leukotriene B4 Receptor, BLT2*
TLDR
It is suggested that BLT2 functions as a low affinity receptor, with broader ligand specificity for various eicosanoids, and mediates distinct biological and pathophysiological roles from BLT1.
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Therapeutic Effects of Novel Sphingosine-1-Phosphate Receptor Agonist W-061 in Murine DSS Colitis
TLDR
Th17 and Th1 cells in lamina propria were thought to be the key subsets in the pathogenesis of DSS-induced colitis, and W-061 may be a novel therapeutic strategy to ameliorate acute aggravation of inflammatory bowel diseases.
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K+ Excretion: The Other Purpose for Puddling Behavior in Japanese Papilio Butterflies
TLDR
The purpose of puddling for male Papilio butterflies is not only to absorb Na+ to correct deficiencies but also to excrete excessive K+.
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Arachidonate 12-lipoxygenase of rat pineal glands: catalytic properties and primary structure deduced from its cDNA.
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Efficacy and immunomodulatory actions of ONO‐4641, a novel selective agonist for sphingosine 1‐phosphate receptors 1 and 5, in preclinical models of multiple sclerosis
TLDR
In a rat experimental autoimmune encephalomyelitis (EAE) model, ONO‐4641 suppressed the onset of disease and inhibited lymphocyte infiltration into the spinal cord in a dose‐dependent manner at doses of 0·03 and 0·1 mg/kg.
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Diurnal change of arachidonate 12-lipoxygenase in rat pineal gland.
TLDR
The 12-lipoxygenase of rat pineal glands shows a diurnal fluctuation that is regulated at the transcription level, and may play a certain role in the regulation of neuroendocrine processes of this gland.
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Structure-activity relationship studies of S1P agonists with a dihydronaphthalene scaffold.
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Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P1 and S1P5 Selective Agonist for the Treatment of Autoimmune Diseases.
The discovery of 1-({6-[(2-methoxy-4-propylbenzyl)oxy]-1-methyl-3,4-dihydronaphthalen-2-yl}methyl)azetidine-3-carboxylic acid 13n (ceralifimod, ONO-4641), a sphingosine-1-phosphate (S1P) receptor…
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Structure-activity relationship studies of sphingosine-1-phosphate receptor agonists with N-cinnamyl-β-alanine moiety.
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Discovery of S1P agonists with a dihydronaphthalene scaffold.
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