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Role of the CXCL8-CXCR1/2 Axis in Cancer and Inflammatory Diseases
The chemokine receptors CXCR1/2 and their ligand CXCL8 are essential for the activation and trafficking of inflammatory mediators as well as tumor progression and metastasis. The CXCL8-CXCR1/2Expand
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Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity.
Herein, we report for the first time the design and synthesis of a novel cyclotide able to efficiently inhibit HIV-1 viral replication by selectively targeting cytokine receptor CXCR4. This wasExpand
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Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort
BackgroundOnly a limited number of studies have performed comprehensive investigations of coding variation in relation to breast cancer risk. Given the established role of estrogens in breast cancer,Expand
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A novel phenylcyclohex‐1‐enecarbothioamide derivative inhibits CXCL8‐mediated chemotaxis through selective regulation of CXCR2‐mediated signalling
Since the CXC chemokine receptor CXCR2 and its cognate ligand CXCL8 (IL‐8) critically regulate neutrophil trafficking during inflammation, they have been implicated in a number of inflammatory lungExpand
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Role of the CXCL 8-CXCR 1 / 2 Axis in Cancer and Inflammatory Diseases
The chemokine receptors CXCR1/2 and their ligand CXCL8 are essential for the activation and trafficking of inflammatory mediators as well as tumor progression and metastasis. The CXCL8-CXCR1/2Expand
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Discovery of Novel CXCR2 Inhibitors Using Ligand-Based Pharmacophore Models
TLDR
Using a CXCR2-inhibitor-based pharmacophore model, we identified a novel set of sulfonamides from a diverse library of small molecules. Expand
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Pyrimidine-based compounds modulate CXCR2-mediated signaling and receptor turnover.
Chemokine receptor CXCR2 is expressed on various immune cells and is essential for neutrophil recruitment and angiogenesis at sites of acute and chronic inflammation caused by tissue injury orExpand
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Overcoming doxorubicin-resistance in the NCI/ADR-RES model cancer cell line by novel anthracene-9,10-dione derivatives.
Overcoming drug resistance with remarkable cytotoxic activity by anthracene-9,10-dione derivatives would offer a potential therapeutic strategy. In this study, we report the synthesis and theExpand
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