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Impact of improved treatment of sexually transmitted diseases on HIV infection in rural Tanzania: randomised controlled trial
It is concluded that improved STD treatment reduced HIV incidence by about 40% in this rural population of Tanzania, the first randomised trial to demonstrate an impact of a preventive intervention on HIV incidence in a general population. Expand
PRO2000 vaginal gel for prevention of HIV-1 infection (Microbicides Development Programme 301): a phase 3, randomised, double-blind, parallel-group trial
Although safe, 0·5% PRO 2000 and 2% PRO2000 are not efficacious against vaginal HIV-1 transmission and are not indicated for this use. Expand
Biological and behavioural impact of an adolescent sexual health intervention in Tanzania: a community-randomized trial
The intervention substantially improved knowledge, reported attitudes and some reported sexual behaviours, especially in boys, but had no consistent impact on biological outcomes within the 3-year trial period. Expand
Rates of virological failure in patients treated in a home-based versus a facility-based HIV-care model in Jinja, southeast Uganda: a cluster-randomised equivalence trial
This home-based HIV-care strategy is as effective as is a clinic-based strategy, and therefore could enable improved and equitable access to HIV treatment, especially in areas with poor infrastructure and access to clinic care. Expand
Control of sexually transmitted diseases for HIV-1 prevention: understanding the implications of the Mwanza and Rakai trials
Two randomised controlled trials of sexually transmitted disease (STD) treatment for the prevention of HIV-1 Infection, in Mwanza, Tanzania, and Rakai, Uganda, unexpectedly produced contrastingExpand
Use of antenatal services and delivery care in Entebbe, Uganda: a community survey
Although antenatal services were well utilised, the quality of services varied and access to essential skilled birth attendants remains difficult especially for less educated, poorer women, commonly mediated by financial and transport difficulties. Expand
HIV and Other Sexually Transmitted Infections in a Cohort of Women Involved in High-Risk Sexual Behavior in Kampala, Uganda
Targeted HIV prevention interventions including regular STI screening, voluntary HIV testing and counseling, condom promotion, and counseling for reducing alcohol use are urgently needed in this population of women involved in high-risk sexual behavior in Kampala. Expand
Mortality and loss-to-follow-up during the pre-treatment period in an antiretroviral therapy programme under normal health service conditions in Uganda
About a quarter of subjects eligible for ART did not complete screening and pre-treatment mortality was very high even though patients in this setting were well informed. Expand
Preparedness of Tanzanian health facilities for outpatient primary care of hypertension and diabetes: a cross-sectional survey
Key weaknesses (and strengths) in health systems that should be considered to improve primary care for NCDs in Africa are identified and ways that HIV programmes could serve as a model and structural platform for these improvements are identified. Expand