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Two distinct estrogen‐regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.
TLDR
Using the hPR gene 5′‐flanking sequences as promoter region in chimeric genes, it is shown that a functional promoter directs initiation of hPR mRNAs from the authentic start sites located at +1 and +15.
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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
TLDR
An updated classification of cell death subroutines focusing on mechanistic and essential aspects of the process is proposed, and the utility of neologisms that refer to highly specialized instances of these processes are discussed.
View on Springer
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
TLDR
A nonexhaustive comparison of methods to detect cell death with apoptotic or nonapoptotic morphologies, their advantages and pitfalls is provided and the importance of performing multiple, methodologically unrelated assays to quantify dying and dead cells is emphasized.
View on Nature
A canonical structure for the ligand-binding domain of nuclear receptors
TLDR
Mutant studies support a general mechanism for ligand-induced activation deduced from the comparison of the transcriptionally active RARγ holo- and inactive RXRα apo-LBD structures.
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TIF2, a 160 kDa transcriptional mediator for the ligand‐dependent activation function AF‐2 of nuclear receptors.
TLDR
The cloning of the 160 kDa human nuclear protein TIF2 is reported, which exhibits all properties expected for a mediator of AF‐2 and exhibits partial sequence homology with the recently isolated steroid receptor coactivator SRC‐1, indicating the existence of a novel gene family of nuclear receptor transcriptional mediators.
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Principles for modulation of the nuclear receptor superfamily
TLDR
This review provides a general overview of the mechanism of action of nuclear receptors and explores the various factors that are instrumental in modulating their pharmacology.
View on Nature
The coactivator TIF2 contains three nuclear receptor‐binding motifs and mediates transactivation through CBP binding‐dependent and ‐independent pathways
TLDR
TIF2 exhibited the characteristics expected for a bona fide NR coactivator, in both mammalian and yeast cells, and a peptide encompassing the TIF2 NID inhibited the ligand‐induced AF‐2 activity of several NRs, indicating that NR AF‐ 2 activity is either mediated by endogenous Tif2 or by coactivators recognizing a similar surface on NR holo‐LBDs.
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Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α
The crystal structure of the human retinoid-X receptor RXR-α ligand-binding domain reveals a previously undiscovered fold of an antiparallel α-helical sandwich, packed as dimeric units. Two helices…
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The promise of retinoids to fight against cancer
TLDR
Understanding of the mechanisms that underlie the anti-proliferative action of retinoids will help to exploit the beneficial aspects of this powerful class of compounds for cancer therapy and prevention.
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The nuclear receptor ligand-binding domain: structure and function.
View on PubMed
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