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Antitumor Activity and Mechanism of Action of the Cyclopenta[b]benzofuran, Silvestrol
The results indicate that silvestrol is a potent anti-cancer compound in vivo that exerts its activity by affecting survival pathways as well as angiogenesis, and it is proposed thatsilvestrol mediates its effects by preferentially inhibiting translation of malignancy-related mRNAs. Expand
Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model.
It is established that targeting translation initiation can restore drug sensitivity in vivo and provide an approach to modulating chemosensitivity. Expand
Testing of antifungal natural products: methodologies, comparability of results and assay choice
Antifungal testing of filamentous fungi generally suffers from incomparability of results. In order to illustrate this problem, the polyacetylene falcarindiol and the naphthoquinone juglone, twoExpand
Structural relationships, distribution and biological activities of stemona alkaloids.
Stemona alkaloids represent a unique class of natural products exclusively isolated from the monocotyledonous family Stemonaceae comprising three genera mainly distributed in southeast Asia and showing species-specific accumulation trends towards certain structural types represent valuable chemosystematic criteria. Expand
Alkamides: structural relationships, distribution and biological activity.
  • H. Greger
  • Biology, Medicine
  • Planta medica
  • 1 October 1984
Some olefinic isobutylamides have been shown to possess considerable insecticidal activity and to be effective as molluscicides and cercaricides and thus are of potential use against bilharzia. Expand
Phylogenetic Analyses of Aurantioideae (Rutaceae) Based on Non‐Coding Plastid DNA Sequences and Phytochemical Features
Molecular, chemical, and other data show that none of the subtribes recognized within Aurantioideae reflect phylogenetic relationships, and the monophyly of several larger genera in both tribes is supported by relatively high bootstrap percentages and specific chemical profiles for e.g., Clausena, Micromelum, Glycosmis and Atalantia. Expand
Aglaia (Meliaceae): an evaluation of taxonomic concepts based on DNA data and secondary metabolites.
This study provides the first assessment of the current circumscription of Aglaieae, Aglaia, and its sections and to a more limited extent of species concepts in AgLAia. Expand
Insecticidal pyrido[1,2-a]azepine alkaloids and related derivatives from Stemona species.
Based on the various insecticidal activities of 13 derivatives structure-activity relationships became apparent, the co-occurrence of pyrrolo- and pyridoazepines suggested biosynthetic connections starting from more widespread protostemonine type precursors. Expand
In vitro inhibition of cyclooxygenase and 5-lipoxygenase by alkamides from Echinacea and Achillea species.
Polyunsaturated alkamides isolated from Achillea species, Echinacea angustifolia DC, Anacyclus pyrethrum (L.) Link, and Aaronsohnia pubescens were shown to possess inhibitory activity in in vitro cyclooxygenase (sheep seminal microsomes) and 5-lipoxygenases (porcine leukocytes) assays. Expand
Stemona alkaloids, from traditional Thai medicine, increase chemosensitivity via P-glycoprotein-mediated multidrug resistance.
The result obtained from this study indicated that Stemona alkaloids may play an important role as a P-gp modulator as used in vitro and may be effective in the treatment of multidrug-resistant cancers. Expand