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Pneumococcal conjugate vaccine provides early protective antibody responses in children after related and unrelated allogeneic hematopoietic stem cell transplantation.
Following allogeneic hematopoietic stem cell transplantation (alloHSCT), children are at risk of life-threatening pneumococcal infections. Whereas vaccination with polysaccharide vaccines fails to… Expand
Severe isolated pulmonary Langerhans cell histiocytosis in a 6-year-old girl
- J. Schulze, Richard Kitz, H. Grüttner, H. Schmidt, S. Zielen
- European Journal of Pediatrics
- 30 March 2004
Langerhans cell histiocytosis (LCH) usually affects different organs or bones. Isolated pulmonary disease is rare in childhood. We report about a 6-year-old girl with progressive pulmonary… Expand
Immune recovery in children undergoing allogeneic stem cell transplantation: absolute CD8+CD3+ count reconstitution is associated with survival
To evaluate the correlation between kinetics of immune reconstitution and survival, we prospectively evaluated lymphocyte subsets in 32 paediatric patients undergoing allogeneic stem cell… Expand
IL-2 activated NK cell immunotherapy of three children after haploidentical stem cell transplantation.
- U. Koehl, J. Sörensen, +7 authors D. Schwabe
- Blood cells, molecules & diseases
- 1 November 2004
Natural killer (NK) cells are thought to be of benefit in HLA-mismatched hematopoietic transplantation (H-SCT). Therefore, we developed a protocol for clinical-use expansion of highly enriched and… Expand
Ex vivo expansion of highly purified NK cells for immunotherapy after haploidentical stem cell transplantation in children.
BACKGROUND Allogeneic natural killer (NK) cells are known to show medium to high cytotoxic activity against HLA-nonidentical leukemia or tumor cells. For a possible benefit of post transplant… Expand
Autologous transplantation of CD133 selected hematopoietic progenitor cells in a pediatric patient with relapsed leukemia
A pediatric patient with very early meningeal relapse of his CD34+ CD133− pre-B-ALL was transplanted with 2.5 × 106/kg CD133 selected autologous progenitor cells. Enrichment of CD133+ cells resulted… Expand
Ocular symptoms in children treated with human-mouse chimeric anti-GD2 mAb ch14.18 for neuroblastoma
Abstract. Unusual ocular symptoms observed during intravenous treatment with anti-disialoganglioside antibody (Ab) in children suffering from neuroblastoma were analyzed and the results reported.… Expand
Human herpes virus‐6 DNA in cerebrospinal fluid of children undergoing therapy for acute leukaemia
alone (54Æ4%) (P < 0Æ01). Those treated with XRT + surgery (81Æ9%) had a better 5-year DSS than those treated with surgery alone (79Æ6%) or XRT alone (71Æ9%) (P < 0Æ01). However, multivariate… Expand
Novel WT1 mutation, 11p LOH, and t(7;12) (p22;q22) chromosomal translocation identified in a Wilms Tumor Case
- R. Löbbert, G. Klemm, H. Grüttner, D. Harms, A. Winterpacht, B. Zabel
- Biology, Medicine
- Genes, chromosomes & cancer
- 1 April 1998
About 5–10% of sporadic Wilms' tumors (WT) are associated with mutations in the Wilms' tumor 1 gene (WT1). More than 90% of patients with Denys‐Drash syndrome (DDS; characterized by renal… Expand
15 parameters of coagulation and fibrinolysis in children with type I diabetes mellitus (onset period).
- M. Koert, U. Nowak‐Göttl, W. Kreuz, H. Grüttner, B. Kornhuber, H. Breddin
- Klinische Padiatrie
- 1 November 1991
15 parameters of coagulation and fibrinolysis were investigated in 38 children with type I diabetes mellitus without clinical signs of diabetic angiopathy. Compared to an age matched non diabetic… Expand