Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist
The Establishment of GABAergic and Glutamatergic Synapses on CA1 Pyramidal Neurons is Sequential and Correlates with the Development of the Apical Dendrite
- R. Tyzio, A. Represa, I. Jorquera, Y. Ben-Ari, H. Gozlan, L. Aniksztejn
- BiologyJournal of Neuroscience
- 1 December 1999
It is proposed that different sets of conditions are required for the establishment of functional GABA and glutamate synapses, the latter necessitating more developed neurons that have apical dendrites that reach the lacunosum moleculare region.
The selective 5-HT1A antagonist radioligand [3H]WAY 100635 labels both G-protein-coupled and free 5-HT1A receptors in rat brain membranes.
Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats
The selective degeneration of serotoninergic neurons produced by an intracerebral injection of 5,7- dihydroxytryptamine was associated only with a significant loss of 5- HT1A binding to the dorsal raphe nucleus and of 3H-8-hydroxy-2- (N-dipropylamino)tetralin as the ligand.
Anoxic LTP sheds light on the multiple facets of NMDA receptors
Identification of presynaptic serotonin autoreceptors using a new ligand: 3H-PAT
3H-PAT seems to be a useful ligand for studying the biochemical and pharmacological characteristics of presynaptic autoreceptors in selected regions of rat brain.
Presynaptic 5-HT autoreceptors on serotonergic cell bodies and/or dendrites but not terminals are of the 5-HT1A subtype.
Interneurons set the tune of developing networks
Early sequential formation of functional GABAA and glutamatergic synapses on CA1 interneurons of the rat foetal hippocampus
- S. Hennou, I. Khalilov, D. Diabira, Y. Ben-Ari, H. Gozlan
- BiologyEuropean Journal of Neuroscience
- 1 July 2002
Interneurons follow the same GABA–glutamate sequence of synapse formation but earlier than the principal cells, and are thus in a position to modulate the development of the hippocampus in the foetal stage.
Altering cannabinoid signaling during development disrupts neuronal activity.
- C. Bernard, M. Milh, Y. Morozov, Y. Ben-Ari, T. Freund, H. Gozlan
- BiologyProceedings of the National Academy of Sciences…
- 28 June 2005
It is reported that retrograde signaling involving endocannabinoids is responsible for the homeostatic control of synaptic transmission and the resulting network patterns in the immature hippocampus.