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The crossed phrenic phenomenon: a model for plasticity in the respiratory pathways following spinal cord injury.
Hemisection of the cervical spinal cord rostral to the level of the phrenic nucleus interrupts descending bulbospinal respiratory pathways, which results in a paralysis of the ipsilateralExpand
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Invited Review: The crossed phrenic phenomenon: a model for plasticity in the respiratory pathways following spinal cord injury
Hemisection of the cervical spinal cord rostral to the level of the phrenic nucleus interrupts descending bulbospinal respiratory pathways, which results in a paralysis of the ipsilateral hemidiaph...
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Spontaneous Functional Recovery in a Paralyzed Hemidiaphragm Following Upper Cervical Spinal Cord Injury in Adult Rats
Previous studies have shown that latent respiratory pathways can be activated by as phyxia or systemic theophylline administration to restore function to a hemidiaphragm paralyzed by C2 spinal cordExpand
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The role of cervical afferent nerve fiber inhibition of the crossed phrenic phenomenon
Abstract High cervical spinal cord hemisection produces a permanent paralysis of the ipsilateral hemidiaphragm. In many species, function is restored to this paretic hemidiaphragm if theExpand
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The crossed phrenic phenomenon and recovery of function following spinal cord injury
  • H. Goshgarian
  • Biology, Medicine
  • Respiratory Physiology & Neurobiology
  • 30 November 2009
This review will focus on neural plasticity and recovery of respiratory function after spinal cord injury and feature the "crossed phrenic phenomenon" (CPP) as a model for demonstrating suchExpand
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Glutamate receptor plasticity and activity-regulated cytoskeletal associated protein regulation in the phrenic motor nucleus may mediate spontaneous recovery of the hemidiaphragm following chronic
High cervical spinal cord hemisection results in paralysis of the ipsilateral hemidiaphragm; however, functional recovery of the paralyzed hemidiaphragm can occur spontaneously. The mechanismsExpand
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Effect of Spinal Cord Injury on the Respiratory System: Basic Research and Current Clinical Treatment Options
Abstract Summary: Spinal cord injury (SCI) often leads to an impairment of the respiratory system. The more rostral the level of injury, the more likely the injury will affect ventilation. In fact,Expand
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Ventral respiratory group projections to phrenic motoneurons: Electron microscopic evidence for monosynaptic connections
The hypothesis that excitatory drive is transmitted monosynaptically from bulbospinal medullary respiratory neurons to spinal respiratory motoneurons was tested by an ultrastructural analysis of theExpand
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Decussation of bulbospinal respiratory axons at the level of the phrenic nuclei in adult rats: A possible substrate for the crossed phrenic phenomenon
The axonal trajectories of inspiratory bulbospinal neurons were examined after deposition of the anterograde neuronal tracer phaseolus vulgaris leucoagglutinin (PHA-L) into the rostral ventralExpand
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Serotonin(2) receptors mediate respiratory recovery after cervical spinal cord hemisection in adult rats.
The aim of the present study was to specifically investigate the involvement of serotonin [5-hydroxytryptamine (5-HT(2))] receptors in 5-HT-mediated respiratory recovery after cervical hemisection.Expand
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