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Activation of the innate immune receptor Dectin-1 upon formation of a “phagocytic synapse”
The ‘phagocytic synapse’ now provides a model mechanism by which innate immune receptors can distinguish direct microbial contact from detection of microbes at a distance, thereby initiating direct cellular antimicrobial responses only when they are required. Expand
C9orf72 is required for proper macrophage and microglial function in mice
It is found that two independent mouse lines lacking the C9orf72 ortholog in all tissues developed normally and aged without motor neuron disease, and altered microglial function may contribute to neurodegeneration in C 9orf72 expansion carriers. Expand
Dectin-1 Stimulation by Candida albicans Yeast or Zymosan Triggers NFAT Activation in Macrophages and Dendritic Cells1
NFAT activation in myeloid cells is established as a novel mechanism of regulation of the innate antimicrobial response and regulates cytokine production by zymosan-stimulated dendritic cells. Expand
Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and
As ERK and p38 MAP kinases differentially regulate the induction of the macrophage effector molecules, inducible NO synthase and IL-12, these kinases are potential targets not only for the development of novel strategies to combat intracellular pathogens but also for therapeutic immunomodulation. Expand
Information processing during phagocytosis
How information is acquired during phagocytosis is discussed and how it is processed to coordinate an immune response is discussed. Expand
β‐glucan recognition by the innate immune system
This review explores what is currently known about β‐glucan recognition and how this recognition stimulates immune responses, and special emphasis is placed on Dectin‐1, as the authors know the most about how this key β‐ glucan receptor translates recognition into intracellular signaling, stimulates cellular responses,and participates in orchestrating the adaptive immune response. Expand
Gut microbiota promote hematopoiesis to control bacterial infection.
Findings reveal that gut bacteria direct innate immune cell development via promoting hematopoiesis, contributing to the appreciation of the deep evolutionary connection between mammals and their microbiota. Expand
Immunomodulation via Novel Use of TLR4 by the Filarial Nematode Phosphorylcholine-Containing Secreted Product, ES-621
This is the first report to demonstrate that modulation of cytokine responses by a pathogen product can be abrogated in cells derived fromTLR4 knockout, but not C3H/HeJ mice, suggesting the existence of a novel mechanism of TLR4-mediated immunomodulation. Expand
The many faces of ITAMs.
Elucidating the diversity of ITAM-based signaling mechanisms will clarify how activating signals generated by ITAMs are tightly regulated and will open opportunities for specific therapeutic manipulation of ITam- based signaling pathways. Expand
Granulocyte‐Monocyte Progenitors and Monocyte‐Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes
SUMMARY Granulocyte‐monocyte progenitors (GMPs) and monocyte‐dendritic cell progenitors (MDPs) produce monocytes during homeostasis and in response to increased demand during infection. BothExpand