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The two distinct phospholipases C of Listeria monocytogenes have overlapping roles in escape from a vacuole and cell-to-cell spread
- G. Smith, H. Marquis, S. Jones, N. Johnston, D. Portnoy, H. Goldfine
- BiologyInfection and immunity
- 1 November 1995
The results of this study were consistent with the two bacterial PLCs having overlapping functions throughout the course of intracellular infection, and the PC-P LC, and possibly PI-PLC, appeared to be enzymatically active intrACEllularly.
A mutation in PCSK9 causing autosomal-dominant hypercholesterolemia in a Utah pedigree
Familial hypercholesterolemia results from mutations in the low-density lipoprotein (LDL) receptor or apolipoprotein B genes. We have previously reported the identification of a Utah…
Listeria monocytogenes Phospholipase C-Dependent Calcium Signaling Modulates Bacterial Entry into J774 Macrophage-Like Cells
Inhibitors that affected calcium signaling changed the Kinetics of association of wild-type bacteria with J774 cells, the kinetics of entry, and the efficiency of escape from the primary phagosome.
The transfer of choline from the host to the bacterial cell surface requires glpQ in Haemophilus influenzae
Testing whether other choline‐containing molecules associated with eukaryotic membranes could provide an alternative source of choline found H. influenzae was able to use glycerophosphorylcholine, an abundant degradation product of phospholipids, as efficiently as free choline.
Listeria monocytogenes mutants lacking phosphatidylinositol-specific phospholipase C are avirulent
It is shown that the facultative intracellular bacterial pathogen, Listeria monocytogenes, contains a gene, plcA, predicting a polypeptide with 31% amino acid identity to a Bacillus thuringiensis PI-PLC.
Listeria monocytogenes : pathogenesis and host response
A 20-Year Perspective on Listeria monocytogenes Pathogenesis, which highlights the importance of knowing the carrier and removal status of canine coronavirus, as a source of infection for humans.
Membrane permeabilization by Listeria monocytogenes phosphatidylinositol-specific phospholipase C is independent of phospholipid hydrolysis and cooperative with listeriolysin O.
- H. Goldfine, C. Knob, D. Alford, J. Bentz
- BiologyProceedings of the National Academy of Sciences…
- 28 March 1995
Data support a postulated accessory role for PI-PLC with LLO in lysing the primary phagosome of a macrophage in a liposome lysis assay and the rate of binding of each protein was not influenced by the presence of the other.
Bacterial membranes and lipid packing theory.
- H. Goldfine
- BiologyJournal of lipid research
- 15 December 1984
Two groups of bacteria that are either natural fatty acid auxotrophs or utilize exogenous fatty acids when endogenous synthesis is inhibited, Acholeplasma laidlawii and the butyric acid-producing clostridia, are capable of adjusting their lipid class compositions according to the degree of unsaturation of their lipid aliphatic chains.
Alterations in the Outer Membrane of the Cell Envelope of Heptose-Deficient Mutants of Escherichia coli
The composition of the cell envelope of a heptose-deficient lipopolysaccharide mutant of Escherichia coli, GR467, was studied after fractionation into its outer and cytoplasmic membrane components by means of sucrose density gradient centrifugation and it was found that major envelope proteins which were localized in the outer membrane were greatly diminished.
The appearance, disappearance and reappearance of plasmalogens in evolution.
- H. Goldfine
- BiologyProgress in lipid research
- 1 October 2010