H. Gilbert

Publications561
h-index84
Citations23,304
Highly Influential Citations1,070
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Carbohydrate-binding modules: fine-tuning polysaccharide recognition.
TLDR
The present review summarizes the impact structural biology has had on the understanding of the mechanisms by which CBMs bind to their target ligands.
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Recognition and Degradation of Plant Cell Wall Polysaccharides by Two Human Gut Symbionts
Competition for nutrients contained in diverse types of plant cell wall-associated polysaccharides may explain the evolution of substrate-specific catabolic gene modules in common bacterial members…
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Understanding the Biological Rationale for the Diversity of Cellulose-directed Carbohydrate-binding Modules in Prokaryotic Enzymes*
TLDR
The differential recognition of cell walls of diverse origin provides a biological rationale for the diversity of cellulose-directed CBMs that occur in cell wall hydrolases and conversely reveals the variety of cellulOSE microstructures in primary and secondary cell walls.
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Cellulosomes: highly efficient nanomachines designed to deconstruct plant cell wall complex carbohydrates.
TLDR
Recent structural and functional studies have revealed how cohesin-dockerin interactions mediate both cellulosome assembly and cell-surface attachment, while retaining the spatial flexibility required to optimize the catalytic synergy within the enzyme complex.
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The Biochemistry and Structural Biology of Plant Cell Wall Deconstruction
  • H. Gilbert
  • Engineering
    Plant Physiology
  • 20 April 2010
The cell walls of plants are the most abundant source of organic carbon on the planet. This photosynthetically fixed carbon is recycled by microbial enzymes that convert cell wall polysaccharides to…
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Restricted access of proteins to mannan polysaccharides in intact plant cell walls.
TLDR
It is shown that molecular recognition of mannan polysaccharides present in intact cell walls is severely restricted and that the masking of primary cell wall mannan by pectin is a potential mechanism for controlling cell wall micro-environments.
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Advances in understanding the molecular basis of plant cell wall polysaccharide recognition by carbohydrate-binding modules.
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Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism
TLDR
Genomic comparison with B. thetaiotaomicron in conjunction with cell culture studies show that a cohort of highly successful members of the microbiota has evolved to consume sterically-restricted yeast glycans, an adaptation that may reflect the incorporation of eukaryotic microorganisms into the human diet.
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Glycan complexity dictates microbial resource allocation in the large intestine
TLDR
It is shown that sharing the breakdown products of complex carbohydrates by key members of the microbiota, such as Bacteroides ovatus, is dependent on the complexity of the target glycan.
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How the walls come crumbling down: recent structural biochemistry of plant polysaccharide degradation.
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