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Effects of intensive blood-pressure control in type 2 diabetes mellitus.
TLDR
In patients with type 2 diabetes at high risk for cardiovascular events, targeting a systolic blood pressure of less than 120 mm HG, as compared with less than 140 mm Hg, did not reduce the rate of a composite outcome of fatal and nonfatal major cardiovascular events. Expand
Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview
TLDR
Stress hyperglycaemia with myocardial infarction is associated with an increased risk of in-hospital mortality in patients with and without diabetes; the risk of congestive heart failure or cardiogenic shock is also increased in patients without diabetes. Expand
Effects of intensive glucose lowering in type 2 diabetes.
TLDR
The use of intensive therapy to target normal glycated hemoglobin levels for 3.5 years increased mortality and did not significantly reduce major cardiovascular events and identify a previously unrecognized harm of intensive glucose lowering in high-risk patients with type 2 diabetes. Expand
Effects of combination lipid therapy in type 2 diabetes mellitus.
TLDR
The routine use of combination therapy with fenofibrate and simvastatin to reduce cardiovascular risk in the majority of high-risk patients with type 2 diabetes does not support the routine use. Expand
Lixisenatide in Patients with Type 2 Diabetes and Acute Coronary Syndrome.
TLDR
In patients with type 2 diabetes and a recent acute coronary syndrome, the addition of lixisenatide to usual care did not significantly alter the rate of major cardiovascular events or other serious adverse events. Expand
Basal insulin and cardiovascular and other outcomes in dysglycemia.
TLDR
Although it reduced new-onset diabetes, insulin glargine also increased hypoglycemia and modestly increased weight and had a neutral effect on cardiovascular outcomes and cancers. Expand
Stress Hyperglycemia and Prognosis of Stroke in Nondiabetic and Diabetic Patients: A Systematic Overview
TLDR
A systematic review and meta-analysis of the literature relating acute poststroke glucose levels to the subsequent course predicted increased risk of in-hospital mortality after ischemic stroke in nondiabetic patients and increase risk of poor functional recovery in nond iabetic stroke survivors. Expand
Effects of medical therapies on retinopathy progression in type 2 diabetes.
TLDR
Intensive glycemic control and intensive combination treatment of dyslipidemia, but not intensive blood-pressure control, reduced the rate of progression of diabetic retinopathy. Expand
Cognitive decline and dementia in diabetes—systematic overview of prospective observational studies
TLDR
Compared to people without diabetes, people with diabetes have a greater rate of decline in cognitive function and a greater risk of cognitive decline and cognitive dysfunction should be added to the list of chronic complications of diabetes. Expand
Evidence-based medicine. A new approach to teaching the practice of medicine.
TLDR
An important goal of the medical residency program is to educate physicians in the practice of evidence-based medicine, and strategies include a weekly, formal academic half-day for residents devoted to learning the necessary skills. Expand
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