• Publications
  • Influence
Identification and Functional Characterization of Allosteric Agonists for the G Protein-Coupled Receptor FFA2
TLDR
This is the first report describing the identification of novel allosteric modulators with agonist activity for FFA2, and these compounds may serve as tools for further unraveling the physiological functions of the receptor and its involvement in various diseases. Expand
Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids.
TLDR
In a mouse in vivo model, the activation of GPR43 by acetate results in the reduction in plasma free fatty acid levels without inducing the flushing side effect that has been observed by theactivation of nicotinic acid receptor, GPR109A. Expand
Treating Diabetes and Obesity with an FGF21-Mimetic Antibody Activating the βKlotho/FGFR1c Receptor Complex
TLDR
It is shown that an antibody mimic of FGF21 works to regulate glucose and insulin homeostasis, leading to weight loss and glucose tolerance in monkeys, and early efficacy data in nonhuman primates suggest that this antibody is on its way to helping treat patients with diet-induced obesity and diabetes. Expand
FGF19-induced Hepatocyte Proliferation Is Mediated through FGFR4 Activation
  • X. Wu, H. Ge, +8 authors Y. Li
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 15 December 2009
TLDR
It is determined that amino acids residues 38–42 of FGF19 are sufficient to confer bothFGFR4 activation and increased hepatocyte proliferation in vivo to FGF21, suggesting that activation of FGFR4 is the mechanism whereby FGF 19 can increase hepatocytes proliferation and induce hepatocellular carcinoma formation. Expand
The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulators.
TLDR
The discovery and optimization of phenylacetamides as allosteric agonists of FFA2 are described, showing that these novel ligands can suppress adipocyte lipolysis in vitro and reduce plasma FFA levels in vivo, suggesting that theseAllosteric modulators can serve as pharmacological tools for exploring the potential function of F FA2 in various disease conditions. Expand
Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects.
TLDR
The acute glucose-lowering and insulin-sensitizing effects of FGF21 are potentially associated with its metabolic actions in liver and adipose tissues. Expand
Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19)
  • X. Wu, H. Ge, +8 authors Y. Li
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 26 July 2010
TLDR
The structural determinants dictating differential receptor interactions that explain and distinguish these two physiological functions are identified and the structural basis underpinning the distinct proliferative feature of FGF19 compared with FGF21 is identified. Expand
Differential regulation and properties of angiopoietin-like proteins 3 and 4 Published, JLR Papers in Press, May 1, 2005. DOI 10.1194/jlr.M500005-JLR200
  • H. Ge, J. Cha, +4 authors Cai Li
  • Biology, Medicine
  • Journal of Lipid Research
  • 1 July 2005
TLDR
Evidence is provided that although there are no intermolecular disulfide bonds evident in Angptl3, higher molecular weight forms do exist and it is suggested that the differential regulation of Angiopoietin-like protein 3 and AngPTl4 by sites of expression, nutritional status, and ligands of nuclear receptors may confer unique roles of each in lipoprotein metabolism. Expand
Inhibition of cardiac lipoprotein utilization by transgenic overexpression of Angptl4 in the heart.
TLDR
The hypothesis that induction of Angptl4 in the heart inhibits lipoprotein-derived fatty acid delivery is supported and will be useful to elucidate the role of reduced fatty acid supply in the pathogenesis of heart failure and related disorders. Expand
Modulation of direct leptin signaling by soluble leptin receptor.
TLDR
It is demonstrated that when SLR is incubated with free leptin, binding of leptin to OB-Rb is reduced, with corresponding decrease of leptin-induced STAT3 tyrosine phosphorylation and STAT3-luc activity, but by preparing leptin/SLR mixtures containing the same amount of free leptin but increasing amounts of SLR complex, it is shown that leptin-SLR complex does not inhibit OB- Rb activation by free leptin. Expand
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