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Reversible unfolding of individual titin immunoglobulin domains by AFM.
Single-molecule atomic force microscopy (AFM) was used to investigate the mechanical properties of titin, the giant sarcomeric protein of striated muscle. Individual titin molecules were repeatedlyExpand
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Sequence-dependent mechanics of single DNA molecules
Atomic force microscope–based single-molecule force spectroscopy was employed to measure sequence-dependent mechanical properties of DNA by stretching individual DNA double strands attached between aExpand
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Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles.
Cytotoxicity of CdSe and CdSe/ZnS nanoparticles has been investigated for different surface modifications such as coating with mercaptopropionic acid, silanization, and polymer coating. For allExpand
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Adhesion forces between individual ligand-receptor pairs.
The adhesion force between the tip of an atomic force microscope cantilever derivatized with avidin and agarose beads functionalized with biotin, desthiobiotin, or iminobiotin was measured. UnderExpand
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Single-cell force spectroscopy
The controlled adhesion of cells to each other and to the extracellular matrix is crucial for tissue development and maintenance. Numerous assays have been developed to quantify cell adhesion. AmongExpand
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Unfolding pathways of individual bacteriorhodopsins.
Atomic force microscopy and single-molecule force spectroscopy were combined to image and manipulate purple membrane patches from Halobacterium salinarum. Individual bacteriorhodopsin molecules wereExpand
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Single Molecule Force Spectroscopy on Polysaccharides by Atomic Force Microscopy
Recent developments in piconewton instrumentation allow the manipulation of single molecules and measurements of intermolecular as well as intramolecular forces. Dextran filaments linked to a goldExpand
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Single molecule force spectroscopy of spectrin repeats: low unfolding forces in helix bundles.
Spectrin repeats fold into triple helical coiled-coils comprising approximately 106 amino acid residues. Using an AFM-related technique we measured the force required to mechanically unfold theseExpand
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Elastically Coupled Two-Level Systems as a Model for Biopolymer Extensibility
We present Monte Carlo simulations for the elasticity of biopolymers consisting of segments that can undergo conformational transitions. Based on the thermodynamics of an elastically coupled twolevelExpand
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Mechanical stability of single DNA molecules.
Using a modified atomic force microscope (AFM), individual double-stranded (ds) DNA molecules attached to an AFM tip and a gold surface were overstretched, and the mechanical stability of the DNAExpand
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