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Selenium: Biochemical Role as a Component of Glutathione Peroxidase
- J. T. Rotruck, A. Pope, H. Ganther, A. Swanson, D. G. Hafeman, W. Hoekstra
- 9 February 1973
When hemolyzates from erythrocytes of selenium-deficient rats were incubated in vitro in the presence of ascorbate or H2O2, added glutathione failed to protect the hemoglobin from oxidative damage.… Expand
Selenium: biochemical role as a component of glutathione peroxidase.
- J. T. Rotruck, A. L. Pope, H. Ganther, A. Swanson, D. G. Hafeman, W. Hoekstra
- Chemistry, Medicine
- 27 April 2009
When hemolyzates from erythrocytes of selenium-deficient rats were incubated in vitro in the presence of ascorbate or H(2)O(2), added glutathione failed to protect the hemoglobin from oxidative… Expand
Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase.
- H. Ganther
- Medicine, Biology
- 1 September 1999
Numerous studies in animal models and more recent studies in humans have demonstrated cancer chemopreventive effects with Se. There is extensive evidence that monomethylated forms of Se are critical… Expand
In vitro and in vivo studies of methylseleninic acid: evidence that a monomethylated selenium metabolite is critical for cancer chemoprevention.
Previous research suggested that the beta-lyase-mediated production of a monomethylated selenium metabolite from Se-methylselenocysteine is a key step in cancer chemoprevention by this agent. In an… Expand
Caspases as key executors of methyl selenium-induced apoptosis (anoikis) of DU-145 prostate cancer cells.
Apoptosis induction may be a mechanism mediating the anticancer activity of selenium. Our earlier work indicated that distinct cell death pathways are likely involved in apoptosis induced by the… Expand
Selenium: Relation to Decreased Toxicity of Methylmercury Added to Diets Containing Tuna
Japanese quail given 20 parts per million of mercury as methylmercury in diets containing 17 percent (by weight) tuna survived longer than quail given this concentration of methylmercury in a… Expand
Reduction of the selenotrisulfide derivative of glutathione to a persulfide analog by glutathione reductase.
- H. Ganther
- Chemistry, Medicine
- 26 October 1971
Delineation of the molecular basis for selenium-induced growth arrest in human prostate cancer cells by oligonucleotide array.
Despite the growing interest in selenium intervention of prostate cancer in humans, scanty information is currently available on the molecular mechanism of selenium action. Our past research… Expand
Monomethyl selenium–specific inhibition of MMP‐2 and VEGF expression: Implications for angiogenic switch regulation
Previous work suggested that antiangiogenic activity may be a novel mechanism contributing to the cancer chemopreventive activity of selenium (Se). Because methylselenol has been implicated as an in… Expand
Selenium‐induced inhibition of angiogenesis in mammary cancer at chemopreventive levels of intake
- C. Jiang, W. Jiang, C. Ip, H. Ganther, J. Lu
- Biology, Medicine
- Molecular carcinogenesis
- 1 December 1999
The trace element nutrient selenium (Se) has been shown to possess cancer‐preventive activity in both animal models and humans, but the mechanisms by which this occurs remain to be elucidated.… Expand