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Selenium: Biochemical Role as a Component of Glutathione Peroxidase
When hemolyzates from erythrocytes of selenium-deficient rats were incubated in vitro in the presence of ascorbate or H2O2, added glutathione failed to protect the hemoglobin from oxidative damage.…
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Selenium: biochemical role as a component of glutathione peroxidase.
When hemolyzates from erythrocytes of selenium-deficient rats were incubated in vitro in the presence of ascorbate or H(2)O(2), added glutathione failed to protect the hemoglobin from oxidative…
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Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase.
  • H. Ganther
  • Biology, Chemistry
    Carcinogenesis
  • 1 September 1999
TLDR
A novel chemopreventive mechanism is proposed involving Se catalysis of reversible cysteine/disulfide transformations that occur in a number of redox-regulated proteins, including transcription factors, which would allow normalization of critical cellular processes in the early stages of transformation.
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In vitro and in vivo studies of methylseleninic acid: evidence that a monomethylated selenium metabolite is critical for cancer chemoprevention.
TLDR
In vitro experiments showed that methylseleninic acid was more potent than Se-methylselenocysteine in inhibiting cell accumulation and inducing apoptosis in TM12 and TM2H mouse mammary hyperplastic epithelial cells, and these effects were not attributable to DNA damage.
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Reduction of the selenotrisulfide derivative of glutathione to a persulfide analog by glutathione reductase.
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Caspases as key executors of methyl selenium-induced apoptosis (anoikis) of DU-145 prostate cancer cells.
TLDR
The data support a methyl selenium-specific induction of DU-145 cell apoptosis that involves cell detachment as a prerequisite (anoikis) and is executed principally through caspase-8 activation and its cross-talk with multiple caspases.
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Selenium: Relation to Decreased Toxicity of Methylmercury Added to Diets Containing Tuna
Japanese quail given 20 parts per million of mercury as methylmercury in diets containing 17 percent (by weight) tuna survived longer than quail given this concentration of methylmercury in a…
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Monomethyl selenium–specific inhibition of MMP‐2 and VEGF expression: Implications for angiogenic switch regulation
TLDR
The hypothesis that the monomethyl Se pool is a proximal Se for inhibiting the expression of MMP‐2 and VEGF and of angiogenesis is supported and the methyl Se–specific inhibitory effects on these proteins are rapid and primary actions, preceding or independent of inhibitory Effects on mitogenic signaling at the level of MAPK1/2.
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Delineation of the molecular basis for selenium-induced growth arrest in human prostate cancer cells by oligonucleotide array.
TLDR
The present study demonstrates the utility of a genome-wide analysis to elucidate the mechanism of selenium chemoprevention and provides valuable insights into novel biological effects ofSelenium, such as inhibition of cell invasion, DNA repair, and stimulation of transforming growth factor beta signaling.
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Selenium‐induced inhibition of angiogenesis in mammary cancer at chemopreventive levels of intake
TLDR
Results indicate a potential for Se metabolites to inhibit key attributes (proliferation, survival, and matrix degradation) of endothelial cells critical for angiogenic sprouting in mammary carcinomas.
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