H. -G. Sahl

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Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies

Robert E. W. Hancock, H. -G. Sahl
Nature Biotechnology
2006

Short cationic amphiphilic peptides with antimicrobial and/or immunomodulatory activities are present in virtually every life form, as an important component of (innate) immune defenses. These… (More)

Failures in clinical treatment of Staphylococcus aureus Infection with daptomycin are associated with alterations in surface charge, membrane phospholipid asymmetry, and drug binding.

Tiffanny L Jones, Michael R Yeaman, +6 authors Arnold S. Bayer
Antimicrobial agents and chemotherapy
2008

Increasingly frequent reports have described the in vivo loss of daptomycin susceptibility in association with clinical treatment failures. The mechanism(s) of daptomycin resistance is not well… (More)

In vitro assembly of a complete, pentaglycine interpeptide bridge containing cell wall precursor (lipid II-Gly5) of Staphylococcus aureus.

Tanja Schneider, Maria Magdalena Senn, Brigitte Berger-Bächi, Alessandro Tossi, H. -G. Sahl, Imke Wiedemann
Molecular microbiology
2004

Staphylococcus aureus peptidoglycan is cross-linked via a characteristic pentaglycine interpeptide bridge. Genetic analysis had identified three peptidyltransferases, FemA, FemB and FemX, to catalyse… (More)

The mode of action of the lantibiotic lacticin 3147--a complex mechanism involving specific interaction of two peptides and the cell wall precursor lipid II.

Imke Wiedemann, Tim Böttiger, +8 authors H. -G. Sahl
Molecular microbiology
2006

Lacticin 3147 is a two-peptide lantibiotic produced by Lactococcus lactis in which both peptides, LtnA1 and LtnA2, interact synergistically to produce antibiotic activities in the nanomolar… (More)

Albert Haas and Chitosan as an Antibacterial Compound Insights into the Mode of Action of

Dina Raafat, Kristine von Bargen, Albert Haas, H. -G. Sahl
2008

Insights into in vivo activities of lantibiotics from gallidermin and epidermin mode-of-action studies.

Raquel R Bonelli, Tanja Schneider, H. -G. Sahl, Imke Wiedemann
Antimicrobial agents and chemotherapy
2006

The activity of lanthionine-containing peptide antibiotics (lantibiotics) is based on different killing mechanisms which may be combined in one molecule. The prototype lantibiotic nisin inhibits… (More)

Insight into invertebrate defensin mechanism of action: oyster defensins inhibit peptidoglycan biosynthesis by binding to lipid II.

Paulina Schmitt, Miriam Wilmes, +5 authors Delphine Destoumieux-Garzón
The Journal of biological chemistry
2010

Three oyster defensin variants (Cg-Defh1, Cg-Defh2, and Cg-Defm) were produced as recombinant peptides and characterized in terms of activities and mechanism of action. In agreement with their… (More)

An oldie but a goodie - cell wall biosynthesis as antibiotic target pathway.

Tanja Schneider, H. -G. Sahl
International journal of medical microbiology…
2010

Bacterial cell wall biosynthesis represents the target pathway for penicillin, the first antibiotic that was clinically applied on a large scale. Penicillin, by means of its beta-lactam ring,… (More)

Production of the Novel Two-Peptide Lantibiotic Lichenicidin by Bacillus licheniformis DSM 13

Jasmin Dischinger, Michaele Josten, Christiane Szekat, H. -G. Sahl, Gabriele Bierbaum
PloS one
2009

BACKGROUND Lantibiotics are small microbial peptide antibiotics that are characterized by the presence of the thioether amino acids lanthionine and methyllanthionine. Lantibiotics possess structural… (More)

Physiology and antibiotic susceptibility of Staphylococcus aureus small colony variants.

Nicole Baumert, Christof von Eiff, Franziska Schaaff, Georg Peters, Richard A. Proctor, H. -G. Sahl
Microbial drug resistance
2002

Small colony variants (SCV) are slow-growing subpopulations with altered metabolism and reduced antibiotic susceptibility which, in the case of Staphylococcus aureus, can cause persisting and… (More)

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