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Expression of accessory molecules for T-cell activation in peripheral nerve of patients with CIDP and vasculitic neuropathy.
Vasculitic neuropathy and chronic inflammatory demyelinating polyneuropathy (CIDP) are neuropathies characterized by a T-lymphocyte infiltrate in the peripheral nerves. The microenvironment in whichExpand
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Selective depletion of major and minor histocompatibility antigen reactive T cells: towards prevention of acute graft‐versus‐host disease
Development of acute graft‐versus‐host disease (aGVHD) following HLA‐identical sibling bone marrow transplantation (BMT) remains a serious complication. Aselective depletion of T cells has proved toExpand
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Human B7-1 is more efficient than B7-2 in providing co-stimulation for alloantigen-specific T cells.
Besides a signal via the T cell receptor/CD3 complex, an additional costimulatory signal is required for optimal T cell activation. This signal can be delivered by interaction of either B7-1 or B7-2Expand
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B7-1 (CD80) as target for immunotoxin therapy for Hodgkin's disease.
In this preclinical study, the potential applicability of an anti-B7-1 immunotoxin (IT) for the treatment of Hodgkin's disease (HD) was investigated. Immunohistochemical analysis demonstrated strongExpand
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Prevalence and clinical significance of resistance to perforin- and FAS-mediated cell death in leukemia
Killer lymphocytes play a central therapeutic role in graft-versus-leukemia following allogeneic hematopoietic stem cell transplantation (HSCT). The Perforin/Granzyme and FAS/CD95 pathways are ofExpand
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A class II‐restricted cytotoxic T‐cell clone recognizes a human minor histocompatibility antigen with a restricted tissue distribution
Following a human leucocyte antigen (HLA)‐identical allogeneic stem cell transplantation (allo‐SCT), minor histocompatibility antigens (mHags) play an important role in the induction ofExpand
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Rheumatoid factor production in the joint.
Mononuclear cells derived from bone marrow, synovium and peripheral blood of patients with rheumatoid arthritis (RA) were examined for their capacity to produce rheumatoid factor (RF) in order toExpand
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Primary human keratinocytes as targets in predicting acute graft‐versus‐host disease following HLA‐identical bone marrow transplantation
Graft‐versus‐host‐disease (GVHD) remains a major problem following allogeneic bone marrow transplantation (BMT) and manifests itself mainly by damage to epithelial cells of the skin, gut and bileExpand
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Determination of helper T‐cell precursor frequencies against non‐haemopoietic cells: comparison of co‐stimulation provided by anti‐CD28 antibody versus the cellular ligand B7‐1
Helper T‐cell precursor frequency assays (HTLp‐assays) are commonly used in transplantation to examine the frequency of T cells reactive against donor or host alloantigens. In these assays,Expand
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