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Oligomerization of KCC2 Correlates with Development of Inhibitory Neurotransmission
The neuron-specific K+–Cl− cotransporter KCC2 extrudes Cl− and renders GABA and glycine action hyperpolarizing. Thus, it plays a pivotal role in neuronal inhibition. Development-dependent KCC2Expand
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Mutation of CDH23, encoding a new member of the cadherin gene family, causes Usher syndrome type 1D
Usher syndrome type I (USH1) is an autosomal recessive disorder characterized by congenital sensorineural hearing loss, vestibular dysfunction and visual impairment due to early onset retinitisExpand
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Expression and Function of Chloride Transporters during Development of Inhibitory Neurotransmission in the Auditory Brainstem
Glycine and GABA, the dominant inhibitory neurotransmitters in the CNS, assume a depolarizing role in early development, leading to increased cytoplasmic Ca2+ levels and action potentials. The effectExpand
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Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation
X-linked forms of mental retardation (XLMR) include a variety of different disorders and may account for up to 25% of all inherited cases of mental retardation. So far, seven X-chromosomal genesExpand
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A novel gene encoding an SH3 domain protein is mutated in nephronophthisis type 1
Juvenile nephronophthisis (NPH), an autosomal recessive cystic kidney disease, is the primary genetic cause of chronic renal failure in children. About two thirds of patients with NPH carry a largeExpand
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Mouse Dac, a novel nuclear factor with homology to Drosophila dachshund shows a dynamic expression in the neural crest, the eye, the neocortex, and the limb bud
Dac is a novel nuclear factor in mouse and humans that shares homology with Drosophila dachshund (dac). Alignment with available sequences defines a conserved box of 117 amino acids that shares weakExpand
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Developmental pattern of three vesicular glutamate transporters in the rat superior olivary complex
Vesicular glutamate transporters (VGLUTs) mediate the packaging of the excitatory neurotransmitter glutamate into synaptic vesicles. Three VGLUT subtypes have been identified so far, which areExpand
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CIP1 is an activator of the K+-Cl- cotransporter KCC2.
In most neurons, efficient setting of the intracellular Cl(-)-concentration requires the coordinated regulation of the Cl(-)-inward transporter NKCC1 and the Cl(-)-outward transporter KCC2.Expand
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KCC2 regulates actin dynamics in dendritic spines via interaction with β-PIX
In neurons, KCC2 controls glutamatergic synaptogenesis and regulates actin polymerization in dendritic spines by binding β-PIXb and attenuating its GEF activity toward small GTPase Rac1.
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Cav1.3 Calcium Channels Are Required for Normal Development of the Auditory Brainstem
Within the Cav1 family of voltage-gated calcium channels, Cav1.2 and Cav1.3 channels are the predominant subtypes in the brain. Whereas specific functions for each subtype were described in the adultExpand
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