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An update on sphingosine-1-phosphate and other sphingolipid mediators.
TLDR
Preclinical and clinical investigations using pharmacological agents that target sphingosine-1-phosphate, its receptors and the enzymes required for its biosynthesis and degradation demonstrate the promise and potential risks of modulating sphingOSine- 1- phosphate signaling in treatment strategies for autoimmunity, cancer, cardiovascular disease and other pathological conditions. Expand
gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis.
TLDR
It is demonstrated that gammaT and mixed vitamin E forms induce cell death by interrupting the de novo sphingolipid pathway in a prostate cancer cell line, which may be valuable as anticancer agents. Expand
Activation of Sphingosine Kinase-1 Reverses the Increase in Lung Vascular Permeability Through Sphingosine-1-Phosphate Receptor Signaling in Endothelial Cells
TLDR
The hypothesis that released S 1P in a paracrine manner activates its receptor S1P1 to restore the endothelial barrier to suggest the crucial role of activation of the SPHK1→S1P→S 1P1 signaling pathway in response to inflammatory mediators in endothelial cells in regulating endothelial Barrier homeostasis is suggested. Expand
Sphingosine-1-Phosphate Enhances Satellite Cell Activation in Dystrophic Muscles through a S1PR2/STAT3 Signaling Pathway
TLDR
It is suggested that S1P promotes SC progression through the cell cycle by repression of cell cycle inhibitors via S1PR2/STAT3-dependent signaling and that SPL inhibition may provide a therapeutic strategy for MD. Expand
Intracellular Role for Sphingosine Kinase 1 in Intestinal Adenoma Cell Proliferation
TLDR
It is shown that Sphk 1 is expressed and is required for small intestinal tumor cell proliferation in ApcMin/+ mice and that inhibitors of Sphk1 may be useful in the control of intestinal cancer. Expand
Accumulation of phosphorylated sphingoid long chain bases results in cell growth inhibition in Saccharomyces cerevisiae.
TLDR
Elevated levels of phosphorylated long chain bases have an antiproliferative effect in yeast and are indicated to inhibit cell growth. Expand
Mammalian acyl-CoA:lysophosphatidylcholine acyltransferase enzymes
TLDR
Characterization of the product of the Aytl2 gene as the phosphatidylcholine reacylating enzyme in RBCs represents the identification of a plasma membrane lysophospholipid acyltransferase and establishes the function of a LPCAT protein. Expand
S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the heart.
TLDR
Results reveal, for the first time, that SPL is an ischemia-induced enzyme that can be targeted as a novel strategy for preventing cardiac I/R injury. Expand
Chemopreventive sphingadienes downregulate Wnt signaling via a PP2A/Akt/GSK3β pathway in colon cancer.
TLDR
The cumulative findings indicate that SDs inhibit Wnt signaling through a protein phosphatase 2A/Akt/GSK3β-dependent mechanism that may contribute to their chemopreventive effects in intestinal tumorigenesis. Expand
Characterization of the Drosophila Sphingosine Kinases and Requirement for Sk2 in Normal Reproductive Function*
TLDR
The associated phenotypes indicate that Sk1 and Sk2 are not redundant in biological function and that sphingosine kinase is essential for diverse physiological functions in this organism. Expand
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