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Tumor necrosis factor and endotoxin in the pathogenesis of liver and pulmonary injuries after orthotopic liver transplantation in the rat
TLDR
It is demonstrated that endotoxemia occurred in the early postoperative stage, followed by elevation of levels of tumor necrosis factor in blood, which may contribute to the pathogenesis of primary nonfunction of the graft and pulmonary complications after orthotopic liver transplantation. Expand
[Anti-allergic effects of tazanolast [butyl 3'-(1H-tetrazol-5-yl) oxanilate, WP-833] metabolites].
TLDR
MTCC [3'-(1H-tetrazol-5-yl) oxanilic acid], the main metabolite of WP-833, dose-dependently inhibited 48-hr homologous passive cutaneous anaphylaxis (PCA) in rats and 8-day PCA in guinea pigs after intravenous administration and showed a dose-dependent inhibition on the release of histamine or slow reacting substance of anaphYLaxis (SRS-A). Expand
Tazanolast(WP-833)代謝物の抗アレルギー作用
WP-833の代謝物である3'-(1H-tetrazol-5-y1)oxanilic acid(MTCC),3-(1H-tetrazol-5-yl)aniline(MTA)および3'-(1H-tetrazol-5-yl)acetanilide(MTAA)のラットおよびモルモットhomologous passive cutaneousExpand