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Naturally-Occurring Neospora caninum Infection in an Adult Sheep and Her Twin Fetuses
TLDR
Histopathological examination of the ewe revealed N. caninum tissue cysts and focal gliosis with mononuclear cell cuffings in an adult sheep, the first report of N.Caninum infection in twin ovine fetuses and in anAdult sheep. Expand
Interferon-γ promotes abortion due to Brucella infection in pregnant mice
TLDR
Results indicate that abortion induced by B. abortus infection is a result of transient IFN-γ production during the period of placental development, which is likely to prevent abortion. Expand
Effect of intraventricular infusion of anti-prion protein monoclonal antibodies on disease progression in prion-infected mice.
TLDR
Although the effects on survival varied for different prion strains, the anti-PrP mAb could partly prevent disease progression, even after clinical onset, suggesting immunotherapy as a candidate for treatment of prion diseases. Expand
Inactivation of Integrin-linked Kinase Induces Aberrant Tau Phosphorylation via Sustained Activation of Glycogen Synthase Kinase 3β in N1E-115 Neuroblastoma Cells*
TLDR
It is reported that ILK controls tau phosphorylation via regulation of glycogen synthase kinase-3β (GSK-3 β) activity in N1E-115 cells, which suggests that endogenous ILK protects against GSK- 3β-induced aberrant tau phosphate levels via inhibition of GSK -3β activity inN1E -115 cells. Expand
LARVA MIGRANS BY BAYLISASCARIS TRANSFUGA: FATAL NEUROLOGICAL DISEASES IN MONGOLIAN JIRDS, BUT NOT IN MICE
TLDR
Critical differences in host reactions against larvae localized in the brain of mice and jirds were found; B. transfuga larvae found in mice were surrounded by granulomatous reactions and immobilized, whereas larvae in j birds were free from any host reaction and mobile, causing extensive malacia. Expand
Distribution of PrP(Sc) in cattle with bovine spongiform encephalopathy slaughtered at abattoirs in Japan.
Three 80- to 95-month-old Holstein dairy cattle infected naturally with the agent of bovine spongiform encephalopathy (BSE) and slaughtered at abattoirs in Japan were examined for the distribution ofExpand
Isolation of Neospora caninum From the Brain of a Pregnant Sheep
Neospora caninum was isolated from the brain of a naturally infected pregnant sheep by inoculation of immunodeficient mice with a homogenate of the brain tissue. The ewe showed no clinical signs.Expand
Genetically modified Shiga toxin 2e (Stx2e) producing Escherichia coli is a vaccine candidate for porcine edema disease.
TLDR
A mutant that retained immunogenicity but lost Vero cell cytotoxicity was constructed, which produced genetically modified toxin (Stx2e*) by replacing glutamate with glutamine at position 167 and arginine with leucine at position 170 of the A subunit, showing that YT106 might be a good candidate of a live attenuated vaccine strain to protect against ED. Expand
Histopathological and immunohistochemical studies of intracranial nervous-system tumours in four cattle.
TLDR
Histopathological examination revealed four types of tumour: intracranial malignant peripheral nerve sheath tumour (MPNST), choroid plexus papilloma, differentiated fibrillary astrocytoma and anaplastic (malignant) astroCytoma. Expand
Effective antigen-retrieval method for immunohistochemical detection of abnormal isoform of prion proteins in animals
TLDR
An improved hydrated autoclaving method at 135°C, more effectively enhanced PrPSc immunoreactivity for the antibodies recognizing the linear epitope and was more effective for the long-term fixation samples as compared with other previous methods. Expand
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