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A network model for the organization of type IV collagen molecules in basement membranes.
Type IV collagen was solubilized from a tumor basement membrane either by acid extraction or by limited digestion with pepsin. The two forms were similar in composition and the size of theExpand
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Shapes, domain organizations and flexibility of laminin and fibronectin, two multifunctional proteins of the extracellular matrix.
Abstract Laminin from a mouse tumor basement membrane and fibronectin from human blood plasma were examined by electron microscopy using rotary shadowing and negative staining and by transmissionExpand
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Human glioma-mesenchymal extracellular matrix antigen defined by monoclonal antibody.
The distribution and localization of a glioma-associated antigen defined by monoclonal antibody 81C6 has been examined using human cultured cell lines and tissues. Monoclonal antibody 81C6 wasExpand
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Moesin: a member of the protein 4.1-talin-ezrin family of proteins.
Moesin (membrane-organizing extension spike protein, pronounced mó ez in) has previously been isolated from bovine uterus and characterized as a possible receptor protein for heparan sulfate. We nowExpand
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Self-assembly of basement membrane collagen.
The in vitro self-assembly of murine type IV collagen was examined by using biochemical and morphological techniques. Dimeric collagen undergoes a rapid and reversible thermal gelation at neutral pHExpand
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Electron-microscopical approach to a structural model of intima collagen.
Intima collagen was studied by electron microscopy (rotary shadowing and negative staining) and by analytical ultracentrifugation. It was found that the monomeric unit (Mr 170 000) consists of a 105Expand
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Protease resistance and conformation of laminin.
Laminin, obtained from a tumor basement membrane, was treated with neutral proteases (trypsin, chymotrypsin, elastase, subtilisin, Stuphylococcus aureus protease), which all produced similar fragmentExpand
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Laminin polymerization in vitro. Evidence for a two-step assembly with domain specificity.
Laminin, a major structural glycoprotein of basement membranes, has been found to self-associate in vitro into large polymers. The formation of these complexes can be followed by the development ofExpand
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Characterization of collagen peptides by sodium dodecylsulfate-polyacrylamide electrophoresis.
Abstract Collagen α-chains and collagen peptides exhibit a lower electrophoretic mobility in SDS-polyacrylamide electrophoresis than globular proteins of the same size. Slight but significantExpand
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Basement membranes in adenoid cystic carcinoma an immunohistochemical study
Tissue samples from 30 patients with adenoid cystic carcinoma and 20 with adenocarcinoma of salivary gland origin were studied by immunohistochemical staining with specific antibodies to the fourExpand
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