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The protective roles of GLP-1R signaling in diabetic nephropathy: possible mechanism and therapeutic potential.
GLP-1 has a crucial role in protection against increased renal oxidative stress under chronic hyperglycemia, by inhibition of NAD(P)H oxidase, a major source of superoxide, and by cAMP-PKA pathway activation.
Characterization of susceptibility of inbred mouse strains to diabetic nephropathy.
Results indicate that DBA/2J and KK/HlJ mice are more prone to diabetic nephropathy, whereas the most widely used C57BL/6j mice are relatively resistant to development of diabetic neephropathy.
Reduction of renal superoxide dismutase in progressive diabetic nephropathy.
Down-regulation of renal SOD1 and SOD3 may play a key role in the pathogenesis of DN, as observed in the kidneys of diabetic mouse models that exhibit comparable levels of hyperglycemia but different susceptibility to DN.
Importance of physical evaluation using skeletal muscle mass index and body fat percentage to prevent sarcopenia in elderly Japanese diabetes patients
To investigate the prevalence of sarcopenia, its related factors and indicators of physical evaluation in elderly diabetes patients, a large number of patients with diabetes are diagnosed with at least some form of sarc Openia.
Urinary adiponectin excretion is increased in patients with overt diabetic nephropathy.
Parallel increase in urinary excretion rates of immunoglobulin G, ceruloplasmin, transferrin, and orosomucoid in normoalbuminuric type 2 diabetic patients.
In normoalbuminuric diabetic patients, excretion rates of plasma proteins with molecular radii <55 A increased in parallel with each other, and this finding may be explained by renal hemodynamic changes, such as increased intraglomerular hydraulic pressure.
Comparisons of the effects of 12‐week administration of miglitol and voglibose on the responses of plasma incretins after a mixed meal in Japanese type 2 diabetic patients
Both drugs can enhance postprandial GLP‐1 responses and reduce GIP responses and the significant BW reduction by miglitol might be attributable to its strong GIP‐reducing efficacy.
Effects of antidiabetic treatment with metformin and insulin on serum and adipose tissue adiponectin levels in db/db mice.
The results suggest that adiponectin synthesis in adipose tissue may be suppressed under hyperinsulinemic state sustained by insulin treatment, even though hyperglycemia is markedly reduced.