Author pages are created from data sourced from our academic publisher partnerships and public sources.
Chronic effects of different fatty acids and leptin in INS-1 cells.
- T. Kawai, H. Hirose, Y. Seto, H. Fujita, T. Saruta
- Biology, Medicine
- Diabetes research and clinical practice
The effects of long-term exposure of a pancreatic beta cell line, INS-1, to major free fatty acids (FFA; palmitic acid, oleic acid and linoleic acid) and leptin on insulin secretion and cell… Expand
Troglitazone ameliorates lipotoxicity in the beta cell line INS-1 expressing PPAR gamma.
To elucidate the mechanisms by which troglitazone, which is a direct ligand for peroxisome proliferator-activated receptor (PPAR) gamma, ameliorates insulin resistance, we have demonstrated that PPAR… Expand
Combination therapy with PPARγ and PPARα agonists increases glucose-stimulated insulin secretion in db/dbmice
Although peroxisome proliferator-activated receptor (PPAR)γ agonists ameliorate insulin resistance, they sometimes cause body weight gain, and the effect of PPAR agonists on insulin secretion is un...
Pharmacokinetics of Futraful (FT-207) for Clinical Application
Futraful, (FT-207) is a furan conjugated 5-FU which was synthesized by Hiller, et.al. From cooperative studies between Japan and USSR, it has become clear that FT-207 is a masked or transport form.… Expand
Characterization of insulin-dependent diabetes mellitus induced by a new variant (DK-27) of encephalomyocarditis virus in DBA/2 mice.
A murine diabetes mellitus induced with a new diabetogenic variant (DK-27) which we isolated from the M variant of the encephalomyocarditis (EMC) virus was characterized. Male DBA/2 mice (9.5 weeks… Expand
Medical chemistry of polyoxometalates. Part 1. Potent antitumor activity of polyoxomolybdates on animal transplantable tumors and human cancer xenograft
The memory effect of heteropolyoxotungstate (PM-19) pretreatment on infection by herpes simplex virus at the penetration stage.
- K. Dan, K. Miyashita, Y. Seto, H. Fujita, T. Yamase
- Biology, Medicine
- Pharmacological research
- 1 October 2002
The keggin-type heteropolyoxotungstate K(7)[PTi(2)W(10)O(40)].6H(2)O (PM-19) is a potent polyoxometalate (PM) inhibitor of the replication of herpes simplex virus (HSV). Pretreatment of Vero cells… Expand
Mechanism of the Protective Effect of Heteropolyoxotungstate against Herpes Simplex Virus Type 2
The effects of heteropolyoxotungstate (K7[PTi2W10O40]· 6H2O; PM-19) on the replication of herpes simplex virus type 2 (HSV-2) were examined using a semiquantitative polymerase chain reaction of… Expand
Stimulating activity of A-4166 on insulin release in in situ hamster pancreatic perfusion.
Using the in situ hamster pancreatic perfusion system, the stimulating action of A-4166 on insulin release was examined in comparison with that of glibenclamide. Both antidiabetic agents stimulated… Expand