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Chronic effects of different fatty acids and leptin in INS-1 cells.
The effects of long-term exposure of a pancreatic beta cell line, INS-1, to major free fatty acids (FFA; palmitic acid, oleic acid and linoleic acid) and leptin on insulin secretion and cellExpand
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Troglitazone ameliorates lipotoxicity in the beta cell line INS-1 expressing PPAR gamma.
To elucidate the mechanisms by which troglitazone, which is a direct ligand for peroxisome proliferator-activated receptor (PPAR) gamma, ameliorates insulin resistance, we have demonstrated that PPARExpand
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Combination therapy with PPARγ and PPARα agonists increases glucose-stimulated insulin secretion in db/dbmice
Although peroxisome proliferator-activated receptor (PPAR)γ agonists ameliorate insulin resistance, they sometimes cause body weight gain, and the effect of PPAR agonists on insulin secretion is un...
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Pharmacokinetics of Futraful (FT-207) for Clinical Application
Futraful, (FT-207) is a furan conjugated 5-FU which was synthesized by Hiller, et.al. From cooperative studies between Japan and USSR, it has become clear that FT-207 is a masked or transport form.Expand
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Characterization of insulin-dependent diabetes mellitus induced by a new variant (DK-27) of encephalomyocarditis virus in DBA/2 mice.
A murine diabetes mellitus induced with a new diabetogenic variant (DK-27) which we isolated from the M variant of the encephalomyocarditis (EMC) virus was characterized. Male DBA/2 mice (9.5 weeksExpand
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The memory effect of heteropolyoxotungstate (PM-19) pretreatment on infection by herpes simplex virus at the penetration stage.
The keggin-type heteropolyoxotungstate K(7)[PTi(2)W(10)O(40)].6H(2)O (PM-19) is a potent polyoxometalate (PM) inhibitor of the replication of herpes simplex virus (HSV). Pretreatment of Vero cellsExpand
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Mechanism of the Protective Effect of Heteropolyoxotungstate against Herpes Simplex Virus Type 2
The effects of heteropolyoxotungstate (K7[PTi2W10O40]· 6H2O; PM-19) on the replication of herpes simplex virus type 2 (HSV-2) were examined using a semiquantitative polymerase chain reaction ofExpand
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Stimulating activity of A-4166 on insulin release in in situ hamster pancreatic perfusion.
Using the in situ hamster pancreatic perfusion system, the stimulating action of A-4166 on insulin release was examined in comparison with that of glibenclamide. Both antidiabetic agents stimulatedExpand
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