H. Fuder

Publications74
h-index18
Citations1,119
Highly Influential Citations27
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Heteroreceptor-mediated modulation of noradrenaline and acetylcholine release from peripheral nerves.
2 Heteroreceptors Modulat ing Noradrenaline Release .................................. 2.1 Muscarinic Receptors ........................................................................ 2.2 Nicotinic… Expand
An Overview of the Pharmacokinetics of Cilomilast (Ariflo®), a New, Orally Active Phosphodiesterase 4 Inhibitor, in Healthy Young and Elderly Volunteers
The oral pharmacokinetics of cilomilast (Ariflo®) were investtigated in five separate studies in healthy volunteers. Cilomilast was rapidly absorbed, and pharmacokinetics were dose proportional after… Expand
Purinoceptor-mediated modulation by endogenous and exogenous agonists of stimulation-evoked [3H]noradrenaline release on rat iris
SummaryTo investigate whether endogenous purinoceptor agonists affect the sympathetic neurotransmission in the rat isolated iris, and to classify the purinoceptors modulating exocytotic… Expand
AF-DX 116 differentiates between prejunctional muscarine receptors located on noradrenergic and cholinergic nerves
SummaryPrejunctional affinity constants of the cardioselective muscarine receptor antagonist AF-DX 116 (11-[(2[(diethyl-amino)methyl]-1-piperidinyl)acetyl]-5,11-dihydro6 H-pyrido [2,3-b] [1,4]… Expand
Concomitant administration of the α-glucosidase inhibitor voglibose (AO-128) does not alter the pharmacokinetics of glibenclamide
Objective: Voglibose is a new and potent inhibitor of α-glucosidases used for treatment of diabetes mellitus. It increases gastro-intestinal motility and could thus affect absorption of other… Expand
Voglibose (AO-128) is an efficient alpha-glucosidase inhibitor and mobilizes the endogenous GLP-1 reserve.
The alpha-glucosidase inhibitor voglibose (AO-128) was designed to prevent rapid postprandial blood glucose rises in non-insulin-dependent diabetics. We analyzed its effect on the entero-insular axis… Expand
M2 muscarinic receptors on the iris sphincter muscle differ from those on iris noradrenergic nerves.
The pre- and postjunctional affinity constants of a series of muscarinic antagonists were determined in guinea pig and rabbit irises. Field stimulation-evoked [3H]noradrenaline release from… Expand
On the opioid receptor subtype inhibiting the evoked release of 3H-noradrenaline from guinea-pig atria in vitro
Summary1.Guinea-pig isolated atria were incubated and loaded with 3H-(−)-noradrenaline. The intrinsic nerves were stimulated with trains of 5 or 35 field pulses (4 Hz), and the evoked efflux of… Expand
Muscarinic inhibition of [3H]‐noradrenaline release on rabbit iris in vitro: effects of stimulation conditions on intrinsic activity of methacholine and pilocarpine
1 Rabbit isolated irides were loaded with [3H]‐noradrenaline and superfused with Tyrode solution. The inhibition by the muscarinic agonists (±)‐methacholine and pilocarpine of the [3H]‐noradrenaline… Expand
The determination of presynaptic pA2 values of yohimbine and phentolamine on the perfused rat heart under conditions of negligible autoinhibition
1 Rat isolated perfused hearts with the right sympathetic nerves attached were loaded with [3H]‐(—)‐noradrenaline. The nerves were stimulated with up to 40 trains of 10 pulses every min at 1 Hz, and… Expand
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