• Publications
  • Influence
Technological and practical challenges of dry powder inhalers and formulations.
There seems to be a great future for dry powder inhalation as many new areas of interest are explored and with the assistance of new techniques like computational fluid dynamics and emerging particle engineering technologies, this is likely to result in a new generation of inhaler devices and formulations, that will enable the introduction of new therapies based on inhaled medicines. Expand
Development of Stable Influenza Vaccine Powder Formulations: Challenges and Possibilities
This review represents the current status of dry stable inactivated influenza vaccine development and the challenges for ultimate market introduction of a stable and effective dry-powder influenza vaccine. Expand
Characterization of the molecular distribution of drugs in glassy solid dispersions at the nano-meter scale, using differential scanning calorimetry and gravimetric water vapour sorption techniques.
It was concluded that temperature modulated differential scanning calorimetry enables characterization and quantification of the molecular distribution in amorphous solid dispersions and when the hygroscopicity of the carrier is reduced by the drug, DVS in combination with TMDSC can be used to estimate the size ofAmorphous drug clusters. Expand
Pulsatile drug delivery to ileo-colonic segments by structured incorporation of disintegrants in pH-responsive polymer coatings.
It is concluded that the structured incorporation of swelling agents in pH-responsive polymers improves the delayed, pulsatile release kinetics of coated capsules. Expand
Inulin, a flexible oligosaccharide I: Review of its physicochemical characteristics.
The physicochemical characteristics of inulin are reviewed, which include morphology (crystal morphology, crystal structure, structure in solution); solubility; rheology; thermal characteristics and physical stability (glass transition temperature, vapor sorption, melting temperature) and chemical stability. Expand
Quality by design approach for optimizing the formulation and physical properties of extemporaneously prepared orodispersible films.
The quality by design (QbD) approach was applied for optimizing the formulation of extemporaneously prepared orodispersible films (ODFs) using Design-Expert® Software and the main factor affecting tensile strength and Young's modulus was the percentage of glycerol. Expand
Breaking of scored tablets: a review.
Performance of score lines can be defined by breaking ease, uniformity of mass of subdivided tablets and loss of mass by the subdivision, and a requirement has been set by the European Pharmacopoeia. Expand
Strongly enhanced dissolution rate of fenofibrate solid dispersion tablets by incorporation of superdisintegrants.
In this study, it was shown that the incorporation of superdisintegrants in solid dispersion tablets containing a high drug load can strongly enhance the dissolution rate of the highly lipophilicExpand
The Effect of Parenterally Administered Cyclodextrins on Cholesterol Levels in the Rat
The hypothesis that complex formation of endogenous cholesterol with cyclodextrins in the bloodstream leads to extraction of cholesterol from the large lipoprotein particles is tested and extravascular redistribution was directly demonstrated in histological studies of the kidneys. Expand
The choice of a suitable oligosaccharide to prevent aggregation of PEGylated nanoparticles during freeze thawing and freeze drying.
It is concluded that inulins are preferred as stabilizers over dextrans for various types of PEGylated nanoparticles due to their compatibility with PEG. Expand