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A new sensitive and specific bioassay for lactogenic hormones: measurement of prolactin and growth hormone in human serum.
A bioassay based on the response of the Nb 2 Node lymphoma cells to lactogenic hormones has been developed and the sensitivity of thisBioassay for PRL and hGH in serum exceeds that of RIAs. Expand
Estrogen induces insulin-like growth factor-I expression in the rat uterus.
It is reported that uterine expression of insulin-like growth factor-I (IGF-I), an important mediator of GH action, is increased after 17 beta-estradiol administration to ovariectomized prepubertal rats, the first report of induction of IGF-I expression by estrogen in vivo. Expand
Isolation and characterization of a complementary DNA (galanin) clone from estrogen-induced pituitary tumor messenger RNA.
Results provide the first evidence of a physiological regulator (estrogen) of the expression of the galanin gene and imply that Galanin is secreted by prolactin-secreting tumors. Expand
Epidermal growth factor receptors and effect of epidermal growth factor on growth of human breast cancer cells in long-term tissue culture.
The results show that EGF receptors are not present in all human breast cancer cell lines, and there is no apparent correlation between EGF binding and its mitogenic activity in cell lines with EGF receptor. Expand
Effect of homologous placental lactogens, prolactins, and growth hormones on islet B-cell division and insulin secretion in rat, mouse, and human islets: implication for placental lactogen regulation
The results indicate that placental lactogen directly regulates islet function in several species and is probably the principal hormone responsible for the increased islets function observed during normal pregnancy. Expand
Isolation and identification of a cDNA clone of rat placental lactogen II.
The developing rat placenta expresses two placental lactogens at different stages of pregnancy: rat placental lactogen I from Days 11 to 13 of pregnancy and rat placental lactogen II (rPLII) from DayExpand
Identification, characterization, and regulation of a rat complementary deoxyribonucleic acid which encodes insulin-like growth factor-I.
This study confirms the highly conserved nature of the IGF-I precursor and provides clear evidence for the GH dependence of insulin-like growth factor 1 gene expression in multiple tissues of the rat. Expand
Isolation of a novel prolactin-like cDNA clone from developing rat placenta.
This study provides clear evidence for the existence of considerable amounts of undescribed prolactin-like proteins in late term rat placenta. Expand
Tissue distribution of insulin-like growth factor I and II messenger ribonucleic acid in the adult rat.
These studies support the notion of paracrine or autocrine function for IGF-I and demonstrate tissue-specific IGF-II expression in the adult rat. Expand
Radioreceptor assay for growth hormone.
ABSTRACT A sensitive radioreceptor assay (RRA) capable of detecting 0.2 ng of human growth hormone (hGH) has been developed using plasma membrane fragments derived from the liver of pregnant rabbitsExpand