Histamine in brain — its role in regulation of seizure susceptibility
Therapeutic efficacy of phenobarbital and primidone in canine epilepsy: a comparison.
- D. Schwartz-Porsche, W. Löscher, H. Frey
- Medicine, BiologyJournal of Veterinary Pharmacology and…
- 1 June 1985
Phenobarbital is regarded as the drug of first choice for the treatment of canine epilepsy, and primidone gave rise to signs of liver toxicity in fourteen out of twenty dogs, as indicated by considerable elevations of liver enzyme values.
Pharmacological properties of 3-n-butylamino-4-phenoxy-5-sulfamylbenzoic acid (Bumetanide), a new potent diuretic.
Evaluation of epileptic dogs as an animal model of human epilepsy.
Comparison of pharmacokinetics of antiepileptic drugs showed that some drugs were suited for maintenance therapy in dogs (primidone, phenobarbital, ethosuximide, trimethadione) whereas others appeared not to be ideally suited because of their short half-lives (phenytoin, carbamazepine, valproic acid, diazepam, clonazepam, nitrazepam).
Stimulation-dependent effect of antiepileptic drugs in amygdala kindled rats on both seizure score and duration of afterdischarges.
The benzodiazepines, clonazepam and diazepam, had a differential effect: they suppressed generalized seizures at low doses, whereas afterdischarges were only suppressed incompletely at relatively high doses.
Central monoamines and convulsine thresholds in mice and rats.
Distribution of valproate across the interface between blood and cerebrospinal fluid
Pharmacokinetics of diazepam in the dog.
- W. Löscher, H. Frey
- Chemistry, MedicineArchives internationales de pharmacodynamie et de…
- 1 December 1981
Both diazepam and desmethyldiazepam rapidly passed the blood/CSF barrier and reached steady state concentrations is CSF corresponding to the part not bound to serum proteins, and there was no indication of enzyme induction by this dose regimen.
Transport of GABA at the Blood‐CSF Interface
The results suggest a transport of GABA into and out of CSF, the outward transport being inhibited by probenecid and sodium valproate.