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Inhibition of TRPM2 cation channels by N‐(p‐amylcinnamoyl)anthranilic acid
Owing to its high potency and efficacy ACA can serve, in combination with other blockers, as a useful tool for studying the unknown function of TRPM2 in native cells.
Application of the vibrant soundbridge® to unilateral osseous atresia cases
The objective of this research is to evaluate the active middle ear implant, the Vibrant Soundbridge® (VSB), for hearing rehabilitation of patients with unilateral osseous aural atresia.
N-(p-amylcinnamoyl)anthranilic acid (ACA): a phospholipase A(2) inhibitor and TRP channel blocker.
N-phenylcinnamides, as a new pharmaceutical lead structure, form the first class of synthetic TRP channel blockers and represent a promising start for the development of small organic TRPChannel-specific blockers.
Evidence for a NOD2-independent susceptibility locus for inflammatory bowel disease on chromosome 16p
Results confirm the importance of NOD2 and provide evidence for a second IBD gene located on chromosome 16p and provide areas of interest for further investigation.
Patient selection for upper airway stimulation: is concentric collapse in sleep endoscopy predictable?
Concentric collapse is a somewhat common condition encountered in sleep endoscopy evaluations of PAP alternatives, and cannot be sustainably predicted with anthropometric or sleep assessments.
Prevalence of renal artery stenosis in diabetes mellitus — an autopsy study
The results indicate that renal artery stenosis often goes undetected before autopsy, and the presence of non‐insulin‐dependent diabetes mellitus increases the risk of renal arteries stenosis.
Haplotype structure and association to Crohn's disease of CARD15 mutations in two ethnically divergent populations
Examination of single nucleotide polymorphisms of the CARD15 (NOD2) gene in populations of north-European and Korean descent confirmed that the three disease-associated SNPs occur independently but share a common background haplotype, suggesting a common origin and the possibility of an undiscovered more strongly predisposing mutation.
International consensus on Vibrant Soundbridge® implantation in children and adolescents.
Systematic review to evaluate the safety, efficacy and economical outcomes of the Vibrant Soundbridge for the treatment of sensorineural hearing loss
The VSB turns out to be a highly reliable and a safe device which significantly improves perception of speech in noisy situations with a high sound quality and implantation with the VSB proved to been a cost-effective and justified health care intervention.
Liver biopsy findings in patients with rheumatoid arthritis undergoing longterm treatment with methotrexate.
It is concluded that liver abnormalities in RA are not related to MTX treatment and Mesenchymal changes and parenchymal alterations were very common without statistically significant difference between the 2 groups.