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- Pu Zong, Johnathan D. Tune, H. Fred Downey
- Experimental biology and medicine
- 2005
Few studies have investigated factors responsible for the O2 demand/supply balance in the right ventricle. Resting right coronary blood flow is lower than left coronary blood flow, which is… (More)
- Eugenia B. Manukhina, H. Fred Downey, Robert T Mallet
- Experimental biology and medicine
- 2006
Hypoxia is one of the most frequently encountered stresses in health and disease. The duration, frequency, and severity of hypoxic episodes are critical factors determining whether hypoxia is… (More)
- Pu Zong, Srinath Setty, +6 authors H. Fred Downey
- Experimental biology and medicine
- 2004
This investigation examined cardiac protective effects of normobaric intermittent hypoxia training. Six dogs underwent intermittent hypoxic training for 20 consecutive days in a normobaric chamber… (More)
- Bradley J. Hart, Xiaoming Bian, Patricia A Gwirtz, Srinath Setty, H. Fred Downey
- American journal of physiology. Heart and…
- 2001
This is the first investigation of right ventricular (RV) myocardial oxygen supply/demand balance in a conscious animal. A novel technique developed in our laboratory was used to collect right… (More)
- R B Boatwright, H. Fred Downey, Fouad A. Bashour, George J. Crystal
- Circulation research
- 1980
We assessed transmurally the coronary autoregulatory response to elevated perfusion pressure in 85 anesthetized, open-chest dogs. Steady state and transient flow distributions were measured with 9 ±… (More)
- Shuji Yonekura, Nagaoki Watanabe, J. L. Caffrey, John F. Gaugl, H. Fred Downey
- Circulation research
- 1987
Right coronary autoregulation was assessed in 14 open-chest, anesthetized dogs. In Group 1 (n = 5), the left common and right coronary arteries were cannulated and perfused independently. As coronary… (More)
- Johnathan D. Tune, Clement Yeh, Srinath Setty, Pu Zong, H. Fred Downey
- Basic Research in Cardiology
- 2002
This study tested whether diabetes mellitus impairs coronary blood flow control sufficiently to alter the balance between myocardial oxygen delivery and metabolism. Dogs (n = 7) were instrumented… (More)
- M X He, Shiqiang Wang, H. Fred Downey
- The American journal of physiology
- 1997
To test the role of inorganic phosphate (Pi) in downregulation of myocardial contractile force at the onset of ischemia, Pi of rat hearts was determined with 31P nuclear magnetic resonance… (More)
Vascular endothelial growth factor is increased following coronary artery occlusion in the dog heart
- Liu Jingjing, Bhooma Srinivasan, Xiaoming Bian, H. Fred Downey, Rouel S. Roque
- Molecular and Cellular Biochemistry
- 2000
Vascular endothelial growth factor (VEGF) is a hypoxia-inducible factor expressed into several molecular forms in mammalian tissues of which VEGF120, VEGF164, and VEGF188 are the major isoforms.… (More)
- Peizhen Zhang, H. Fred Downey, Xiangrong Shi
- Experimental biology and medicine
- 2010
Physiological adaptations to intermittent hypoxia (IH) conditioning are based on the cumulative effect of repeated IH exposures. The present study sought to test the hypothesis that acute IH… (More)