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Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
It is suggested that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.
WHO Library Cataloguing-in-Publication Data
Realist review and synthesis of retention studies for health workers in rural and remote areas / Marjolein Dieleman … [et al]. 1.Health services accessibility-organization and administration.…
Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis
As a result of bioassay–guided fractionation, betulinic acid, a pentacyclic triterpene, was identified as a melanoma–specific cytotoxic agent and antitumour activity was mediated by the induction of apoptosis.
Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms.
- J. Liu, J. Burdette, J. Bolton
- Biology, MedicineJournal of agricultural and food chemistry
- 24 March 2001
Genistein was found to be the most effective of four red clover isoflavones tested in the above in vitro assays, suggesting a potential use for some dietary supplements, ingested by human beings, in the treatment of menopausal symptoms.
Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase.
Nigranoic acid showed activity in several anti-HIV reverse transcriptase and polymerase assays and its structure elucidation and unambiguous NMR spectral assignment were achieved by the combination of 1D- and 2D-NMR techniques with the aid of computer modeling.
Mechanistic evaluation of new plant-derived compounds that inhibit HIV-1 reverse transcriptase.
The mechanism of action of 1 beta-hydroxyaleuritolic acid 3-p-Hydroxybenzoate and protolichesterinic acid as HIV-1 RT inhibitors involves nonspecific binding to the enzyme at nonsubstrate binding sites, whereas swertifrancheside inhibits enzyme activity by binding toThe template-primer.
Activity-guided isolation of the chemical constituents of Muntingia calabura using a quinone reductase induction assay.
Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity.
Fractionation of an ethyl acetate-soluble extract of the bark of Artocarpus dadah has led to the isolation of three new prenylated stilbenoid derivatives, 3-(gamma,gamma-dimethylallyl)resveratrol…
Aromatase inhibitors from Broussonetia papyrifera.
- D. Lee, K. Bhat, H. Fong, N. Farnsworth, J. Pezzuto, A. Kinghorn
- ChemistryJournal of natural products
Structural-activity relationships in the aromatase assay were determined for the benzofurans, biphenylpropanoids, coumarins, and various types of flavonoids obtained among a total of 42 constituents of B. papyrifera.
Isolation, structure elucidation, and absolute configuration of 26-deoxyactein from Cimicifuga racemosa and clarification of nomenclature associated with 27-deoxyactein.
A new triterpene glycoside, 26-deoxyactein, is isolated from the roots/rhizomes of Cimicifuga racemosa and the structures and absolute stereochemistry of 1 and 2 were established by spectroscopic methods (FABMS and (13)C NMR) and single-crystal X-ray data analysis.