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Identification of Cathepsin L as a Potential Sex-Specific Biomarker for Renal Damage
The renin-angiotensin system is a well-known regulator of blood pressure and plays an important role in the pathogenesis of cardiovascular disease and renal damage. Genetic factors, including singleExpand
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Serum IL‐5 and IL‐13 consistently serve as the best predictors for the blood eosinophilia phenotype in adult asthmatics
Molecular biomarkers that identify the phenotype of blood eosinophilia were evaluated in adult asthmatics, and their relationship with clinically significant asthma outcomes was assessed. PatientsExpand
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A novel CRTH2 antagonist: Single‐ and multiple‐dose tolerability, pharmacokinetics, and pharmacodynamics of ACT‐453859 in healthy subjects
The chemoattractant receptor‐homologous molecule expressed on T‐helper 2 cells (CRTH2) is a G‐protein‐coupled receptor for prostaglandin D2, a key mediator in inflammatory disorders. In thisExpand
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Impact of high‐altitude therapy on type‐2 immune responses in asthma patients
Asthma patients present with distinct immunological profiles, with a predominance of type 2 endotype. The aim of this study was to investigate the impact of high‐altitude treatment on the clinicalExpand
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Development of a decision-making biomarker for CRTH2 antagonism in clinical studies
Abstract Biomarkers have shown to improve success rates in the development of novel drugs, providing essential information in the early phases of clinical development for decision-making.Expand
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Pharmacokinetics, pharmacodynamics, tolerability and prediction of clinically effective dose of ACT‐774312: A novel CRTH2 antagonist
ACT‐774312 is an antagonist of the chemoattractant receptor‐homologous molecule expressed on T helper (Th) 2 cells (CRTH2), in development for the treatment of nasal polyposis or other allergic andExpand
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Characterisation of an experimental mouse model of exposure to nanoparticles. Relevance to human sarcoidosis
Background: Nanoparticles are increasingly suspected as a strong etiologic factor in sarcoidosis pathogenesis.The aim of our study was to evaluate lung inflammatory response and histology changesExpand
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Development of a smart biomaterial for osseointegration in oral defects
Galway, Ireland Development of a Smart Biomaterial for Osseointegration in Oral Defects C. Mauth, E. Bono, M. de Wild, A. Molenberg, H. Farine, M. Dard, U. Graf-Hausner Corresponding Author:Expand