• Publications
  • Influence
TGFβ2 dictates disseminated tumour cell fate in target organs through TGFβ-RIII and p38α/β signalling
TLDR
A ‘seed and soil’ mechanism where TGF-β2 and T GF-β-RIII signalling through p38α/β regulates DTC dormancy and defines restrictive (BM) and permissive (lung) microenvironments for HNSCC metastasis is revealed. Expand
Telomere structure and telomerase in health and disease
TLDR
This review focuses on the structure and function of the telomere/telomerase complex and its altered behavior leading to disease, mainly cancer. Expand
Antitumor and antiangiogenic activity of soy isoflavone genistein in mouse models of melanoma and breast cancer.
TLDR
The data suggest that tumor cell migration and proteolysis may be associated with the antitumor and antiangiogenic activity of soy isoflavone genistein. Expand
Synergistic interactions of the anti-casein kinase 2 CIGB-300 peptide and chemotherapeutic agents in lung and cervical preclinical cancer models.
TLDR
Findings provide a rationale for combining the anti-CK2 CIGB-300 peptide with currently available anticancer agents in the clinical setting and indicate platins and taxanes as compounds with major perspectives. Expand
CIGB-300, a novel proapoptotic peptide that impairs the CK2 phosphorylation and exhibits anticancer properties both in vitro and in vivo
TLDR
These results provide an early proof-of-principle of clinical benefit by using an anti-CK2 approach in cancer and are the first clinical trial where an investigational drug has been used to target the CK2 phosphorylation domain. Expand
Lovastatin alters cytoskeleton organization and inhibits experimental metastasis of mammary carcinoma cells
TLDR
It is described that pretreatment with a non-cytotoxic concentration of lovastatin (10 μM) dramatically inhibited the metastatic ability of F3II mammary carcinoma cells in syngeneic BALB/c mice and induced a dose-dependent inhibition in the secretion of urokinase, a key proteolytic enzyme during tumor invasion and metastasis. Expand
Reduction of mouse mammary tumor formation and metastasis by lovastatin, an inhibitor of the mevalonate pathway of cholesterol synthesis
TLDR
The present data indicate that lovastatin could be an antitumor agent with potentially useful clinical applications in breast cancer. Expand
Anticancer peptide CIGB-300 binds to nucleophosmin/B23, impairs its CK2-mediated phosphorylation, and leads to apoptosis through its nucleolar disassembly activity
TLDR
Findings provide important clues by which the CIGB-300 peptide exerts its proapoptotic effect on tumor cells and highlights the suitability of the B23/CK2 pathway for cancer-targeted therapy. Expand
Mechanisms of cellular uptake, intracellular transportation, and degradation of CIGB-300, a Tat-conjugated peptide, in tumor cell lines.
TLDR
This work studied differential antiproliferative behavior in terms of cellular uptake, intracellular transportation, and degradation in tumor cell lines with dissimilar sensitivity to CIGB-300 to suggest a mechanism of internalization, vesicular transportation, but also suggests degradation in highly sensitive cells. Expand
Preparation, characterization and in vitro evaluation of ε-polylysine-loaded polymer blend microparticles for potential pancreatic cancer therapy
TLDR
The cytotoxicity and antiproliferative effect of PLL-PB-MPs in pancreatic adenocarcinoma cell lines BxPC3 and MIA PaCa-2 were confirmed and constitute a promising carrier to deliver bioactive peptides. Expand
...
1
2
3
4
5
...