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Methods for evaluating addiction liability. (A) "Attitude" of opiate addicts toward opiate-like drugs. (B) a short-term "direct" addiction test.
A method has been developed for quantifying the "attitude" of addicts toward opiate-like drugs when administered in single or chronic dosages. Questionnaires were used which provided forExpand
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An experimental study of the etiology of rum fits and delirium tremens.
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A comparative study of physiological and subjective effects of heroin and morphine administered intravenously in postaddicts.
Using a variety of subjective and objective measures, the relative potency of heroin to morphine administered intravenously to postaddicts found 1.80 to 2.66 mg of morphine sulfate equal to 1 mg ofExpand
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Studies on lysergic acid diethylamide (LSD-25). I. Effects in former morphine addicts and development of tolerance during chronic intoxication.
The striking mental changes induced by the diethylamide of lysergic acid (hereafter referred to as LSD) have been studied extensively in Europe,* Great Britain,† and the United States.‡ In minuteExpand
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Studies of the dependence-producing potential of the narcotic antagonist 2-cyclopropylmethyl-2'-hydroxy-5,9-dimethyl-6,7-benzomorphan (cyclazocine, WIN-20,740, ARC II-c-3).
The effects of single doses and chronic administration of cyclazocine have been studied in nontolerant postaddicts, as well as in postaddicts physically dependent upon morphine. In addition,Expand
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Actions and addiction liabilities of alpha-acetyl-methadols in man.
1. dl-, d- and l -Alpha-acetylmethadol possess addiction liability. 2. Single subcutaneous or intravenous doses of d -alpha-acetylmethadol in former morphine addicts promptly induced a train ofExpand
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Actions and addiction liabilities of dromoran derivatives in man.
The levorotatory isomers of Dromoran and methyl Dromoran account for all the miotic and respiratory depressant effects of the racemates of these compounds. The dextrorotatory isomers have noExpand
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Electroencephalographic changes in man during use and withdrawal of barbiturates in moderate dosage.
Abstract 1. 1. In contrast to doses of over 0.6 g. per day, the withdrawal of 0.4 g. daily of seconbarbital or pentobarbital after three months was not followed by psychotic or convulsiveExpand
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Chronic barbiturate intoxication: further studies.
ISBELL and co-workers, in 1950, showed that the behavior and neurological status of five patients experimentally intoxicated with large amounts of barbiturates for 92 to 144 days resembled that ofExpand
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