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Methods for evaluating addiction liability. (A) "Attitude" of opiate addicts toward opiate-like drugs. (B) a short-term "direct" addiction test.
A short, "double-blind," direct addiction, cross-over procedure of 18 to 20 days is satisfactory for developing significant degrees of physical dependence in the case of morphine and codeine-like drugs, but additional studies are necessary to determine its reliability for assessing the degree ofPhysical dependence induced by weak compounds and compounds in the methadone and meperidine series.
A comparative study of physiological and subjective effects of heroin and morphine administered intravenously in postaddicts.
  • W. Martin, H. F. Fraser
  • Psychology, Biology
    The Journal of pharmacology and experimental…
  • 1 September 1961
Data acquired during short-term addiction studies did not support the statement that tolerance develops more rapidly to heroin than to morphine, and it was found that postaddicts could identify heroin and morphine as such with a high degree of accuracy when these agents were administered intravenously either on an acute or chronic basis.
Studies of the dependence-producing potential of the narcotic antagonist 2-cyclopropylmethyl-2'-hydroxy-5,9-dimethyl-6,7-benzomorphan (cyclazocine, WIN-20,740, ARC II-c-3).
The bulk of evidence indicates that this agent is qualitatively different from morphine, and cyclazocine should not be classified as a morphine-like analgesic and its potential for abuse by narcotic addicts is regarded as being very low.
Studies on lysergic acid diethylamide (LSD-25). I. Effects in former morphine addicts and development of tolerance during chronic intoxication.
The striking mental changes induced by the diethylamide of lysergic acid (hereafter referred to as LSD) have been studied extensively in Europe, Great Britain and the United States and are apparently the most effective and safest agent for inducing an experimental, but reversible, psychosis in nonpsychotic subjects.
Actions and addiction liabilities of alpha-acetyl-methadols in man.
Single subcutaneous or intravenous doses of d -alpha-acetylmethadol in former morphine addicts promptly induced a train of morphine-like effects which disappeared in less than 24 hours.
Actions and addiction liabilities of dromoran derivatives in man.
The levorotatory isomers of Dromoran and methyl Dromoran account for all the miotic and respiratory depressant effects of the racemates of these compounds. The dextrorotatory isomers have no
Chronic barbiturate intoxication: further studies.
The purpose of the present communication is to extend the series of Isbell and co-workers, from 5 to 19 cases, in order that the variations in the clinical picture of barbiturate addiction, withdrawal, and recovery can be more completely delineated.