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Mechanisms of Oxygen Demand/Supply Balance in the Right Ventricle
Few studies have investigated factors responsible for the O2 demand/supply balance in the right ventricle. Resting right coronary blood flow is lower than left coronary blood flow, which Is… Expand
Normobaric hypoxia conditioning reduces blood pressure and normalizes nitric oxide synthesis in patients with arterial hypertension
- N. P. Lyamina, S. Lyamina, Valery N Senchiknin, R. Mallet, H. F. Downey, E. Manukhina
- Journal of hypertension
- 1 November 2011
Objectives Insufficient production and/or increased decomposition of the potent endogenous vasodilator nitric oxide plays an important role in development and progression of arterial hypertension and… Expand
Intermittent Hypoxia: Cause of or Therapy for Systemic Hypertension?
- T. Serebrovskaya, E. Manukhina, M. Smith, H. F. Downey, R. Mallet
- Experimental biology and medicine
- 1 June 2008
During acute episodes of hypoxia, chemoreceptor-mediated sympathetic activity increases heart rate, cardiac output, peripheral resistance and systemic arterial pressure. However, different… Expand
Role of Nitric Oxide in Cardiovascular Adaptation to Intermittent Hypoxia
Hypoxia is one of the most frequently encountered stresses in health and disease. The duration, frequency, and severity of hypoxic episodes are critical factors determining whether hypoxia is… Expand
Effects of intermittent hypoxia training on exercise performance, hemodynamics, and ventilation in healthy senior men.
- V. Shatilo, O. Korkushko, V. Ischuk, H. F. Downey, T. Serebrovskaya
- High altitude medicine & biology
The efficacy and safety of intermittent hypoxia training (IHT) were investigated in healthy, 60- to 74-yr-old men. Fourteen men (Gr 1) who routinely exercised daily for 20 to 30 min were compared… Expand
Hypoxic preconditioning of ischaemic canine myocardium.
OBJECTIVE The aim was to test whether a brief period of non-ischaemic hypoxia can precondition myocardium. METHODS 60 anaesthetised adult mongrel dogs of either sex underwent 60 min occlusion of… Expand
Increased Lymphatic Flow in the Thoracic Duct During Manipulative Intervention
- E. M. Knott, J. Tune, S. T. Stoll, H. F. Downey
- The Journal of the American Osteopathic…
- 1 October 2005
Abstract The thoracic pump and the abdominal pump are osteopathic manipulative (OM) lymphatic pump techniques frequently used by osteopathic physicians to treat patients with infections (eg,… Expand
Right ventricular oxygen supply/demand balance in exercising dogs.
- B. Hart, X. Bian, P. Gwirtz, S. Setty, H. F. Downey
- American journal of physiology. Heart and…
- 1 August 2001
This is the first investigation of right ventricular (RV) myocardial oxygen supply/demand balance in a conscious animal. A novel technique developed in our laboratory was used to collect right… Expand
Effects of a coronary alpha 1-constriction on transmural left ventricular flow and contractile function.
- P. Gwirtz, J. M. Dodd-o, +4 authors C. E. Jones
- The American journal of physiology
- 1 April 1992
Modulation of myocardial contractile function and perfusion by alpha 1-adrenergic receptors were examined in anesthetized dogs during left stellate ganglion stimulation. In 11 dogs, stellate… Expand
Small vessel and total coronary blood volume during intracoronary adenosine.
The effect of a maximally dilating dose of intracoronary adenosine on total (CBV) and small-vessel blood volume (MSVBV, an index of open-capillary density), hematocrit (MSVHct), and related… Expand