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Stress‐induced visceral hypersensitivity to rectal distension in rats: role of CRF and mast cells
Study of the influence of partial restraint stress on the abdominal cramps induced by rectal distension in rats and the role of corticotropin releasing factor (CRF) and mast cells degranulation in this response found pathways involving central CRF and intestinal mast cells involved.
Guanylate cyclase C‐mediated antinociceptive effects of linaclotide in rodent models of visceral pain
This work investigated the anti‐nociceptive properties of linaclotide in rodent models of inflammatory and non‐inflammatory visceral pain and determined whether these pharmacological effects are linked to the activation of guanylate cyclase C (GC‐C).
A pilot study on faecal MMP-9: a new noninvasive diagnostic marker of colorectal cancer
Faecal MMP-9 may be a promising new noninvasive marker in CRC, and was suitable to distinguish CRC patients from controls and identified high-risk adenomas besides CRC by means of a lower cutoff level.
Acute and chronic stress differently affect visceral sensitivity to rectal distension in female rats
The influence of acute and chronic stress on visceral nociception in female rats and the involvement of colonic mast cells in this effect is investigated and cannot be attributed to a different effect of either stress paradigm on mast cell histamine release.
Lactobacillus farciminis treatment suppresses stress induced visceral hypersensitivity: a possible action through interaction with epithelial cell cytoskeleton contraction
L farciminis treatment prevents stress induced hypersensitivity, increase in colonic paracellular permeability, and colonocyte MLC phosphorylation, and this antinociceptive effect may also involve direct or indirect effects of NO produced by this probiotic.
Mannodendrimers prevent acute lung inflammation by inhibiting neutrophil recruitment
The 3T mannodendrimer represents an innovative fully synthetic compound for the treatment of lung inflammatory diseases and mimicking the bioactive supramolecular structure of mannose-capped lipoarabinomannan.